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Drugs

, Volume 78, Issue 13, pp 1321–1337 | Cite as

Pharmacotherapy for Focal Seizures in Children and Adolescents

  • Clare E. Stevens
  • Carl E. Stafstrom
Review Article
  • 155 Downloads

Abstract

Focal-onset seizures are among the most common forms of seizures in children and adolescents and can be caused by a wide diversity of acquired or genetic etiologies. Despite the increasing array of antiseizure drugs available, treatment of focal-onset seizures in this population remains problematic, with as many as one-third of children having seizures refractory to medications. This review discusses contemporary concepts in focal seizure classification and pathophysiology and describes the antiseizure medications most commonly chosen for this age group. As antiseizure drug efficacy is comparable in children and adults, here we focus on pharmacokinetic aspects, drug–drug interactions, and side effect profiles. Finally, we provide some suggestions for choosing the optimal medication for the appropriate patient.

Notes

Acknowledgements

This work involved no funding source. The authors declare no conflicts of interest.

Compliance with Ethical Standards

Funding

This work involved no funding source.

Conflict of interest

The authors declare no conflicts of interest.

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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Division of Pediatric Neurology, Department of Neurology, Johns Hopkins HospitalThe Johns Hopkins University School of MedicineBaltimoreUSA

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