Comment on “Proton Pump Inhibitor Use and Risk of Developing Alzheimer’s Disease or Vascular Dementia: A Case–Control Analysis”
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The association between proton pump inhibitor (PPI) use and dementia is controversial . In this issue of Drug Safety, Imfeld et al.  reported as follows: “As compared to non-use, long-term PPI use (≥ 100 prescriptions) was not associated with an increased risk of developing AD (Alzheimer’s disease) [aOR (adjusted odds ratio) 0.88, 95% CI (confidence interval) 0.80–0.97] or VaD (vascular dementia) (aOR 1.18, 95% CI 1.04–1.33)” . I am afraid that long-term PPI use (≥ 100 prescriptions) was associated with an increased risk of developing VaD (aOR 1.18, 95% CI 1.04–1.33) as compared to non-use based on the results, because the 95% CI was between 1.04 and 1.33.
Katsuhiro Toda is the only author.
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No funding was received to assist with the preparation of this letter.
Conflict of interest
Katsuhiro Toda has no conflicts of interest that are directly relevant to the content of this letter.
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