CNS Drugs

, Volume 32, Issue 10, pp 891–893 | Cite as

Emergency First-Line Anti-Seizure Medication for Seizures and Status Epilepticus: What is Going Wrong, Doctor?

  • Raoul SutterEmail author

Repetitive and prolonged seizures as well as status epilepticus represent life-threatening neurologic emergencies with serious cerebral and systemic sequela [1]. High morbidity and mortality associated with untreated or uncontrolled seizures call for emergency treatment including airway management, hemodynamic and metabolic stabilization, protection from physical injuries, administration of emergency anti-seizure medication, and the identification and treatment of underlying pathologies. Despite the fact that randomized controlled trials in this context are mostly limited to first-line anti-seizure medication (i.e., benzodiazepines) [2, 3, 4, 5], international collaborations of experts including epileptologists, neurologists, neurointensivists, neurosurgeons, and pharmacologists led to the development of treatment guidelines for prolonged seizures and status epilepticus across the age spectrum [6, 7]. However, such guidelines focus on the in-hospital setting and, despite a number of...


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No funding was received for the preparation of this article.

Conflict of interest

Raoul Sutter received research Grants from the Swiss National Foundation (No. 320030_169379), the Research Fund of the University Basel, the Scientific Society Basel, and the Gottfried Julia Bangerter-Rhyner Foundation. He received personal grants from UCB-Pharma and holds stocks from Novartis and Roche.


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© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Medical Intensive Care Units and Department of NeurologyUniversity Hospital BaselBaselSwitzerland
  2. 2.Medical FacultyUniversity of BaselBaselSwitzerland

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