Emergency First-Line Anti-Seizure Medication for Seizures and Status Epilepticus: What is Going Wrong, Doctor?
- 59 Downloads
Repetitive and prolonged seizures as well as status epilepticus represent life-threatening neurologic emergencies with serious cerebral and systemic sequela . High morbidity and mortality associated with untreated or uncontrolled seizures call for emergency treatment including airway management, hemodynamic and metabolic stabilization, protection from physical injuries, administration of emergency anti-seizure medication, and the identification and treatment of underlying pathologies. Despite the fact that randomized controlled trials in this context are mostly limited to first-line anti-seizure medication (i.e., benzodiazepines) [2, 3, 4, 5], international collaborations of experts including epileptologists, neurologists, neurointensivists, neurosurgeons, and pharmacologists led to the development of treatment guidelines for prolonged seizures and status epilepticus across the age spectrum [6, 7]. However, such guidelines focus on the in-hospital setting and, despite a number of...
Compliance with ethical standards
No funding was received for the preparation of this article.
Conflict of interest
Raoul Sutter received research Grants from the Swiss National Foundation (No. 320030_169379), the Research Fund of the University Basel, the Scientific Society Basel, and the Gottfried Julia Bangerter-Rhyner Foundation. He received personal grants from UCB-Pharma and holds stocks from Novartis and Roche.
- 7.Glauser T, Shinnar S, Gloss D, Alldredge B, Arya R, Bainbridge J, et al. Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr. 2016;16(1):48–61.CrossRefPubMedPubMedCentralGoogle Scholar