Clinical Pharmacokinetics

, Volume 58, Issue 5, pp 615–625 | Cite as

Bridging Olaparib Capsule and Tablet Formulations Using Population Pharmacokinetic Meta-analysis in Oncology Patients

  • Diansong Zhou
  • Jianguo Li
  • Khanh Bui
  • Maria Learoyd
  • Alienor Berges
  • Tsveta Milenkova
  • Nidal Al-Huniti
  • Helen Tomkinson
  • Hongmei XuEmail author
Original Research Article



Olaparib is a first-in-class potent oral poly(ADP-ribose) polymerase inhibitor.


The aims of this analysis were to establish an integrated population pharmacokinetic (PK) model of olaparib in patients with solid tumors and to bridge the PK of olaparib between capsule and tablet formulations.


The population PK model was developed using plasma concentration data from 659 patients in 11 phase I, II, and III studies of olaparib tablets/capsules monotherapy. Relative bioavailability between the tablet and capsule formulations was estimated and the relative exposure between olaparib tablet and capsule therapeutic doses was further assessed.


The concentration–time profile was described using a two-compartment model with sequential zero- and first-order absorption and first-order elimination for both capsules and tablets with different absorption parameters. Multiple-dose clearance compared with single-dose clearance was reduced by approximately 15% (auto-inhibition). Disease severity had an impact on olaparib clearance, and tablet strength had an impact on Ka. The olaparib geometric mean area under the curve (AUC) and maximal concentration (Cmax) following a single 300 mg tablet were 42.1 μg h/mL and 5.8 μg/mL, respectively, and the steady-state geometric mean AUC and Cmax following a 300 mg tablet twice daily were 49.0 μg h/mL and 7.7 μg/mL, respectively. The relative exposure (AUC) of the 300 mg tablet formulation is 13% higher than the 400 mg capsule formulation.


This analysis bridged the olaparib capsule and tablet formulation PK and provided key assessment to support the approval of the olaparib tablet formulation in patients with ovarian cancer, regardless of their BRCA mutation status.



The authors would like to thank the patients, their families, and all investigators and study personnel involved. They would also like to acknowledge the programmers who supported the compilation of the dataset, Mihai Surducan of Mudskipper Ltd for medical writing assistance funded by AstraZeneca, and the FDA pharmacometric reviewers Chao Liu, Jingyu Yu, and Yaning Wang for their comments. This study was sponsored by AstraZeneca.

Compliance with Ethical Standards


This study was funded by AstraZeneca.

Conflict of interest

Diansong Zhou, Maria Learoyd, Alienor Berges, Tsveta Milenkova, Nidal Al-Huniti, Helen Tomkinson, and Hongmei Xu are employees of and shareholders in AstraZeneca. Jianguo Li and Khanh Bui are former employees of AstraZeneca.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in this study.

Supplementary material

40262_2018_714_MOESM1_ESM.docx (30 kb)
Supplementary material 1 (DOCX 20 kb)


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Diansong Zhou
    • 1
  • Jianguo Li
    • 1
  • Khanh Bui
    • 1
  • Maria Learoyd
    • 2
  • Alienor Berges
    • 2
  • Tsveta Milenkova
    • 3
  • Nidal Al-Huniti
    • 1
  • Helen Tomkinson
    • 2
  • Hongmei Xu
    • 1
    Email author
  1. 1.Quantitative Clinical Pharmacology, Early Clinical DevelopmentIMED Biotech Unit, AstraZenecaBostonUSA
  2. 2.Quantitative Clinical Pharmacology, Early Clinical DevelopmentIMED Biotech Unit, AstraZenecaCambridgeUK
  3. 3.Global Medicine Development, AstraZenecaCambridgeUK

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