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Authors’ Reply to “The Challenges of Studying Peripheral Vestibular Vertigo”

  • Arne W. Scholtz
  • Gerhard WeisshaarEmail author
Letter to the Editor
  • 21 Downloads

Dear Editor,

We are grateful to Dr. Naples [1] for his constructive feedback on our article in Clinical Drug Investigation [2], and would like to take this opportunity to address the points raised regarding the particular challenges of studying peripheral vestibular vertigo.

In general, clinical studies on patients with vertigo, whether predominantly of peripheral or central origin, are indeed challenging for a number of reasons. Vertigo is not a disease entity, but a complex set of numerous single symptoms, each subjectively experienced and reported by individual patients. Furthermore, regarding the terminology of vestibular symptoms, there are still different perceptions among experts dealing with vertigo (e.g., otolaryngologists, neurologists) and between countries or geographic regions. Only in 2009, the Committee for Classification of Vestibular Disorders of the Bárány Society published a consensus document in a first attempt to define, harmonize, and classify key vestibular...

Notes

Compliance with Ethical Standards

Funding

No funding was received to prepare this letter.

Conflict of interest

Arne W. Scholtz has no conflicts of interest to declare. Gerhard Weisshaar is an employee of Hennig Arzneimittel.

References

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    Naples JG. The challenges of studying peripheral vestibular vertigo. Clin Drug Investig. 2019.  https://doi.org/10.1007/s40261-019-00871-9 CrossRefGoogle Scholar
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    Scholtz AW, Hahn A, Stefflova B, et al. Efficacy and safety of a fixed combination of cinnarizine 20 mg and dimenhydrinate 40 mg vs betahistine dihydrochloride 16 mg in patients with peripheral vestibular vertigo: a prospective, multinational, multicenter, double-blind, randomized, non-inferiority clinical trial. Clin Drug Investig. 2019;39(11):1045–56.CrossRefGoogle Scholar
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    Scholtz AW, Steindl R, Burchardi N, Bognar-Steinberg I, Baumann W. Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis. A randomized, double-blind, non-inferiority study. Clin Drug Investig. 2012;32(6):387–99.CrossRefGoogle Scholar
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    Scholtz AW, Ilgner J, Loader B, Pritschow B, Weisshaar G. Cinnarizine and dimenhydrinate in the treatment of vertigo in medical practice. Wien Klin Wochenschr. 2016;128:341–7.  https://doi.org/10.1007/s00508-015-0905-5.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.ENT ClinicMedical University of Innsbruck, and ENT Center for VertigoInnsbruckAustria
  2. 2.Hennig Arzneimittel GmbH & Co. KGFloersheim am MainGermany

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