Clinical Drug Investigation

, Volume 39, Issue 12, pp 1255–1258 | Cite as

Non-Vitamin K Antagonist Oral Anticoagulant Treatment in Centenarians: A Series of Four Cases

  • Yuval Kuntzman
  • Eyal Zimlichman
  • Howard Amital
  • Shmuel TiosanoEmail author
Research Letter

The increasing life expectancy has resulted in an ever-increasing proportion of the elderly in the general population [1], and it is estimated that the overall proportion of individuals aged 60 years and above will reach 2 billion by 2050. It is to be expected that the prevalence of age-associated disease, such as atrial fibrillation, will rise in parallel [2]. While there is overwhelming evidence that anticoagulation is critical for stroke prevention in patients diagnosed with atrial fibrillation, anticoagulation is reportedly underprescribed in elderly patients [3]. One of the reasons for withholding anticoagulants is a tendency to overestimate the incidence of intracranial hemorrhage. It has been established that the effectiveness of treatment with non-vitamin K antagonist oral anticoagulant (NOAC) agents is not inferior to that of vitamin K antagonists (VKAs) in populations with an average age of 70–73 years [4]. A 2018 observational study on elderly ethnic Chinese (aged 85 years...


Compliance with Ethical Standards

Ethical Approval

This study was approved by the local Ethics Committee, Sheba Medical Center, Israel (authorization number 4205-17-SMC).

Conflict of interest

Yuval Kuntzman, Eyal Zimlichman, Howard Amital and Shmuel Tiosano declare no conflicts of interest.


No funding was received for this study.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Medicine ‘B’Sheba Medical Center, Tel-HashomerRamat GanIsrael
  2. 2.Zabludowicz Center for Autoimmune DiseasesSheba Medical Center, Tel-HashomerRamat GanIsrael
  3. 3.Sackler Faculty of MedicineTel-Aviv UniversityTel AvivIsrael
  4. 4.ManagementSheba Medical Center, Tel-HashomerRamat GanIsrael

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