Clinical Drug Investigation

, Volume 39, Issue 1, pp 105–107 | Cite as

Comment on: Pharmacokinetics, Pharmacodynamics, and Safety of the Novel Calcimimetic Agent Evocalcet in Healthy Japanese Subjects: First-in-Human Phase I Study

  • Nuggehally R. SrinivasEmail author
Letter to the Editor

Cinacalcet hydrochloride (Sensipar®) has been approved for the treatment of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients [1, 2]. Due to the efficient targeting of calcium sensory receptors present in parathyroid glands, the pharmacodynamic activity elicited by cinacalcet directly leads to the lowering of serum parathyroid hormone (PTH) and reduced serum levels of both calcium and phosphorous [2]. Despite beneficial effects of cinacalcet therapy in CKD patients pertaining to delayed onset of cardiovascular events, gastrointestinal tolerability issues such as nausea and vomiting have been reported [1, 2, 3]. Another drawback of cinacalcet therapy is with regards to cinacalcet being a perpetrator drug for cytochrome P450 (CYP) 2D6 and a victim drug especially for CYP3A4 [4, 5, 6]. In other words, the CYP profile of cinacalcet suggests that it may precipitate the occurrence of potential drug–drug interactions of substrates and inhibitors of CYP2D6 (i.e....


Compliance with Ethical Standards


No funding was received to prepare this letter.

Conflict of Interest

The author has no conflict of interest to declare in the contents of the manuscript, which was solely prepared to exchange clinical pharmacology-related thoughts on a topic of considerable interest.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Zydus Research Centre, a Division of Cadila Healthcare LtdAhmedabadIndia
  2. 2.Jubilant Life Sciences, Innovation and TechnologyNoidaIndia

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