Comment on: “Economic Implications of Pathogen Reduced and Bacterially Tested Platelet Components: A US Hospital Budget Impact Model”

  • Paul MintzEmail author
Letter to the editor

Dear Editor,

I read with interest the Cerus Corp.-sponsored report by Prioli et al. [1] presenting an interactive model of the economic implications associated with different strategies that may be employed to mitigate the risk of bacterial sepsis following platelet transfusion. The model allocates costs to pathogen-reduced platelets produced by the Cerus Intercept process (PR-PC), platelet concentrates tested with a rapid test (RT-PC) (The Platelet PGD Test, Verax Biomedical, Marlborough, MA, USA), and “conventional platelet concentrates” (C-PC), for which neither technology had been used. The authors also include in the model a mix of 50% RT-PC and 50% PR-PC.

The authors have apparently applied the cost of daily testing of platelets using the PGD Test but may not have been aware that the US Food and Drug Administration (FDA) does not require daily testing. The legend for Fig. 3 states: “RT-PC are extended to a 7-day shelf life in this model, and require four secondary rapid bacterial...


Compliance with Ethical Standards


No funding was received for the preparation of this work.

Conflict of interest

The author is an employee of Verax Biomedical Inc., which manufactures and sells the Platelet PGD Test.


  1. 1.
    Prioli KM, Karp JK, Lyons NM, et al. Economic implications of pathogen reduced and bacterially tested platelet components: a US hospital budget impact model. Appl Health Econ Health Policy. 2018. Scholar
  2. 2.
    Platelet PGD Test. Verax Biomedical. Package Insert. Accessed 17 Nov 2018
  3. 3.
    Vauthrin M, Greene M, Weinstein R. Verax platelet PGD test workflow strategy. Transfusion. 2016;56:198-9A (Supplement S4).Google Scholar
  4. 4.
    Transcript of the FDA Blood Product Advisory Committee meeting 30 November 2017. p 182. Accessed 17 Nov 2018
  5. 5.
    Jacobs MR, Smith D, Heaton WA, et al. Detection of bacterial contamination in prestorage culture-negative apheresis platelets on day of issue with the Pan Genera Detection test. Transfusion. 2011;51:2573–82.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Verax BiomedicalMarlboroughUSA

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