Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis
The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association.
We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case–control, cross-sectional, and cohort studies examining the association between psoriasis and vitiligo. A customized Newcastle–Ottawa Scale was used to assess the risk of bias of the included studies. We performed a random effects meta-analysis to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) for case–control and cross-sectional studies.
Of 2453 citations identified from the literature search, 10 case–control/cross-sectional studies with a total of 120,866 psoriasis cases and 79,907 vitiligo cases were included in our study. Four of these studies were rated as high risk of bias. We found a significantly increased odds for vitiligo in psoriasis patients (summary OR 2.29, 95% CI 1.56–3.37, studies = 7), as well as a significantly elevated odds for psoriasis in vitiligo patients (summary OR 3.43, 95% CI 1.86–6.33, studies = 4).
Our meta-analysis showed that psoriasis and vitiligo are associated with each other. Several studies had a high risk of bias, and further investigation is needed to confirm this association and amplify treatment options.
Compliance with Ethical Standards
No funding was received for the conduct of this study or the preparation of this article.
Conflict of interest
Hsi Yen and Ching-Chi Chi have no conflicts of interest directly relevant to the content of this article.
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