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Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis

  • Hsi Yen
  • Ching-Chi Chi
Systematic Review

Abstract

Background

The relationship between psoriasis and vitiligo has not been previously confirmed, and we therefore aimed to investigate this association.

Methods

We conducted a search of the MEDLINE and EMBASE electronic databases on 22 January 2018 for case–control, cross-sectional, and cohort studies examining the association between psoriasis and vitiligo. A customized Newcastle–Ottawa Scale was used to assess the risk of bias of the included studies. We performed a random effects meta-analysis to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) for case–control and cross-sectional studies.

Results

Of 2453 citations identified from the literature search, 10 case–control/cross-sectional studies with a total of 120,866 psoriasis cases and 79,907 vitiligo cases were included in our study. Four of these studies were rated as high risk of bias. We found a significantly increased odds for vitiligo in psoriasis patients (summary OR 2.29, 95% CI 1.56–3.37, studies = 7), as well as a significantly elevated odds for psoriasis in vitiligo patients (summary OR 3.43, 95% CI 1.86–6.33, studies = 4).

Conclusions

Our meta-analysis showed that psoriasis and vitiligo are associated with each other. Several studies had a high risk of bias, and further investigation is needed to confirm this association and amplify treatment options.

Notes

Compliance with Ethical Standards

Funding

No funding was received for the conduct of this study or the preparation of this article.

Conflict of interest

Hsi Yen and Ching-Chi Chi have no conflicts of interest directly relevant to the content of this article.

Supplementary material

40257_2018_394_MOESM1_ESM.pdf (62 kb)
Supplementary material 1 (PDF 62 kb)

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of DermatologyChang Gung Memorial HospitalTaoyuanTaiwan
  2. 2.College of MedicineChang Gung UniversityTaoyuanTaiwan

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