American Journal of Clinical Dermatology

, Volume 20, Issue 3, pp 325–333 | Cite as

Neutrophilic Dermatoses Associated with Myeloid Malignancies

  • Clémence LepelletierEmail author
  • Jean-David Bouaziz
  • Michel Rybojad
  • Martine Bagot
  • Sophie Georgin-Lavialle
  • Marie-Dominique Vignon-Pennamen
Leading Article


Neutrophilic dermatoses (ND) are a group of conditions characterized by an aseptic accumulation of polymorphonuclear leukocytes in the skin. Occurrence of ND in association with myeloid malignancies, mainly myelodysplastic syndrome and myelogenous acute leukemia, is not rare and is often associated with a poor prognosis. Recent findings have improved understanding of the pathophysiology of myeloid malignancy-associated ND. We review the clinical spectrum of myeloid malignancy-associated ND with an emphasis on recently identified mechanisms. Myeloid leukemia cells retain the potential for terminal differentiation into polymorphonuclear leukocytes in the skin. Many studies suggest a clonal link between myeloid malignancies and ND. Activation of autoinflammatory pathways (NOD-like receptor family pyrin domain-containing-3, Familial Mediterranean Fever Gene) in the clonal cells of myeloid disorders may also be involved in this setting.


Compliance with Ethical Standards


No sources of funding were used to conduct this study or prepare this manuscript.

Conflict of interest

CL, J-DB, MR MB, SG-L, and M-DV-P have no conflicts of interest that are directly relevant to the content of this article.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Clémence Lepelletier
    • 1
    • 2
    Email author
  • Jean-David Bouaziz
    • 1
    • 2
  • Michel Rybojad
    • 1
  • Martine Bagot
    • 1
    • 2
  • Sophie Georgin-Lavialle
    • 3
    • 4
  • Marie-Dominique Vignon-Pennamen
    • 5
  1. 1.Assistance Publique-Hôpitaux de Paris, Département de DermatologieHôpital Saint-LouisParisFrance
  2. 2.Université Paris-Diderot, Sorbonne Paris CitéParisFrance
  3. 3.Assistance Publique-Hôpitaux de Paris, Service de Médecine interneHôpital TenonParisFrance
  4. 4.Université Pierre et Marie Curie, Sorbonne Paris CitéParisFrance
  5. 5.Assistance Publique-Hôpitaux de Paris, Département de PathologieHôpital Saint-LouisParisFrance

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