American Journal of Cardiovascular Drugs

, Volume 19, Issue 2, pp 185–193 | Cite as

Optimal Medical Therapy Prescribing Patterns and Disparities Identified in Patients with Acute Coronary Syndromes at an Academic Medical Center in an Area with High Coronary Heart Disease-Related Mortality

  • Ashley N. FoxEmail author
  • Grant H. Skrepnek
  • Jamie L. Miller
  • Nicholas C. Schwier
  • Toni L. Ripley
Original Research Article



Coronary heart disease (CHD)-related mortality is high in the southern United States. A five-drug pharmacotherapy regimen for acute coronary syndromes (ACS), defined as optimal medical therapy (OMT), can decrease CHD-related mortality. Studies have indicated that OMT is prescribed 50–60% of the time. Assessment of prescribing could provide insight into the potential etiology of disparate mortality.


The aim was to evaluate prescribing of OMT at discharge in patients presenting with an ACS event at an academic medical center and identify patients at risk of not receiving OMT.


A single-center, retrospective cohort of patients with ACS diagnosis between July 2013 and July 2015 was investigated, and a multivariable regression analysis conducted to identify populations at risk of not receiving OMT.


A total of 864 patients were identified by International Classification of Diseases, Ninth Revision (ICD-9) codes, with 533 excluded and 331 analyzed. OMT was prescribed in 69.79%. Patients ≥ 75 years of age [p = 0.003; odds ratio (OR) 0.30; 95% confidence interval (CI) 0.136–0.673], unstable angina presentation (p = 0.042; OR 0.55; 95% CI 0.307–0.977), and surgical management (p = 0.001; OR 0.22; 95% CI 0.095–0.519) were less likely to receive OMT.


The percentage of patients prescribed OMT exceeded the reported global percentage of prescribed OMT. However, disparities exist among specific populations.



We would like to acknowledge Chelsea LaPreze, Pharm.D., for her contributions to data collection for this project.

Compliance with Ethical Standards

Conflict of interest

Authors Fox, Miller, Skrepnek, Schwier, and Ripley declare they have no potential conflicts of interest that might be relevant to the contents of this manuscript.


No external funding was used in the preparation of this manuscript. None of the authors received grant support or other types of extramural funding for the writing of this manuscript.


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Pharmacy: Clinical and Administrative SciencesThe University of Oklahoma College of PharmacyOklahoma CityUSA
  2. 2.Department of Pharmacy: Clinical and Administrative SciencesThe University of Oklahoma College of PharmacyOklahoma CityUSA
  3. 3.Department of Pharmacy: Clinical and Administrative SciencesThe University of Oklahoma College of PharmacyOklahoma CityUSA
  4. 4.Department of Pharmacy: Clinical and Administrative SciencesThe University of Oklahoma College of PharmacyOklahoma CityUSA
  5. 5.TRC Healthcare, Pharmacist’s LetterOklahoma CityUSA

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