Advertisement

Chemical Research in Chinese Universities

, Volume 35, Issue 4, pp 686–692 | Cite as

Fabrication and In vitro Bioactivity of Robust Hydroxyapatite Coating on Porous Titanium Implant

  • Mengna Duan
  • Xiaofeng Wu
  • Long Yuan
  • Zhiying Zhang
  • Yan Zhang
  • Yanmin ZhouEmail author
Article
  • 23 Downloads

Abstract

Compared with the traditional dental implant, TixOs® manufactured by direct laser metal forming(DLMF) technology exhibits improved capability for bone osteointegration due to its porous surface structure, and has achieved remarkable clinical effect. However, like the traditional titanium and other alloyed implants, the porous titanium implant TixOs® also has relatively weak bioactivity. To address this issue, a proper surface modification method may be needed. Hydroxyapatite(HA) has been widely used in implant surface coating for its similar chemical composition to bone tissue and its osteoconductive properties. Thus, combining TixOs® implants with hydroxyapatite can be an efficient way to enhance their bioactivity. We herewith reported a competent pulsed laser deposition(PLD) method of coating nano-sized HA thin film onto the porous TixOs® implant. The HA coatings were characterized by means of scanning electron microscopy(SEM), energy dispersive X-ray spectroscopy(EDS), X-ray photoelectron spectroscopy(XPS) and focused ion beam(FIB) method, and nanocrystal sized thin HA films were identified on the surface of TixOs® implants. The low cytotoxicity and improved cell proliferation ability of HA coated implants were further tested and verified using MC 3T3 E1 cells with the consideration of the controlling group. Our results show that a stable and bioactive HA thin film is able to form on the surface of the porous titanium implant by PLD method. This may benefit the further clinical application of TixOs® implants.

Keywords

Hydroxyapatite Pulsed laser deposition Porous titanium Bioactivity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Notes

Acknowledgments

The authors would like to thank the Company of Leader-Novaxa(Italia) for providing TixOs® implants for free.

References

  1. [1]
    Bassetti R. G., Bassetti M. A., Kuttenberger J., Int. J. Prosthodont., 2018, 31, 287CrossRefGoogle Scholar
  2. [2]
    Pelletier H., Carrado A., Faerber J., Mihailescu I. N., Appl. Phys. A, 2011, 102, 629CrossRefGoogle Scholar
  3. [3]
    Rajesh P., Muraleedharan C. V., Komath M., Varma H., J. Mater. Sci. Mater. Med., 2011, 22, 497CrossRefGoogle Scholar
  4. [4]
    Shibli J. A., Grassi S., Piattelli A., Pecora G. E., Ferrari D. S., Onuma T., d’Avila S., Coelho P. G., Barros R., Iezzi G., Clin. Implant Dent. Relat. Res., 2010, 12, 281CrossRefGoogle Scholar
  5. [5]
    Shibli J. A., Grassi S., de Figueiredo L. C., Feres M., Marcantonio E., Iezzi G., Piattelli A., J. Biomed. Mater. Res., Part B, 2010, 80B, 377CrossRefGoogle Scholar
  6. [6]
    Romeo E., Lops D., Margutti E., Ghisolfi M., Chiapasco M., Vogel G., Int. J. Oral Maxillofac. Pathol., 2004, 19, 247Google Scholar
  7. [7]
    Khayat P. G., Milliez S. N., Journal of Oral Implantology, 2007, 33, 225CrossRefGoogle Scholar
  8. [8]
    Mangano C., Shibli J. A., Mangano F., Sammons R., Macchi A., Journal of Osseointegration, 2009, 1, 2Google Scholar
  9. [9]
    Ryan G., Pandit A., Apatsidis D. P., Biomaterials, 2006, 27, 2651CrossRefGoogle Scholar
  10. [10]
    Mangano C., Mangano F., Proceedings of the 2nd International Dental Conference on Future Trend in Implantology (FTI), Florence, Italy, 2011 Google Scholar
  11. [11]
    Liu J. Y., Chen F., Ge Y. J., Wei L., Pan S. X., Feng H. L., Journal of Peking University(Health Sciences), 2018, 50, 117Google Scholar
  12. [12]
    Mangano C., Mangano F., Shibli J. A., Luongo G., de Franco M., Briguglio F., Figliuzzi M., Eccellente T., Rapani C., Piombino M., Macchi A., Lasers in Medical Science, 2012, 27, 181CrossRefGoogle Scholar
  13. [13]
    Nelea V., Ristoscu C., Chiritescu C., Ghica C., Mihailescu I. N., Pelletier H., Mille P., Cornet A., Appl. Surf. Sci., 2000, 168, 127CrossRefGoogle Scholar
  14. [14]
    Duta L., Mihailescu N., Popescu A. C., Luculescu C. R., Mihailescu I. N., Cetin G., Gunduz O., Oktar F. N., Popa A. C., Kuncser A., Besleaga C., Stan G. E., Appl. Surf. Sci., 2017, 413, 129CrossRefGoogle Scholar
  15. [15]
    Capuccini C., Torricelli P., Sima F., Boanini E., Ristoscu C., Bracci B., Socol G., Fini M., Mihailescu I. N., Bigi A., Acta Biomater., 2008, 4, 1885CrossRefGoogle Scholar
  16. [16]
    Sun L. M., Berndt C. C., Gross K. A., Kucuk A., J. Biomed. Mater. Res., 2001, 58, 570CrossRefGoogle Scholar
  17. [17]
    Nelea V., Morosanu C., Iliescu M., Mihailescu I. N., Appl. Surf. Sci., 2004, 228, 346CrossRefGoogle Scholar
  18. [18]
    Kim H. W., Koh Y. H., Li L. H., Lee S., Kim H. E., Biomaterials, 2004, 25, 2533CrossRefGoogle Scholar
  19. [19]
    Kiahosseini S. R., Afshar A., Larijani M. M., Yousefpour M., Appl. Surf. Sci., 2017, 401, 172CrossRefGoogle Scholar
  20. [20]
    Zhitomirsky I., GalOr L., J. Mater. Sci. Mater. Med., 1997, 8, 213CrossRefGoogle Scholar
  21. [21]
    Koch C. F., Johnson S., Kumar D., Jelinek M., Chrisey D. B., Doraiswamy A., Jin C., Narayan R. J., Millailescu I. N., Mater. Sci. Eng. C, 2007, 27, 484CrossRefGoogle Scholar
  22. [22]
    Maxian S. H., Zawadsky J. P., Dunn M. G., J. Biomed. Mater. Res., 1993, 27, 111CrossRefGoogle Scholar
  23. [23]
    GarciaSanz F. J., Mayor M. B., Arias J. L., Pou J., Leon B., PerezAmor M., J. Mater. Sci. Mater. Med., 1997, 8, 861CrossRefGoogle Scholar
  24. [24]
    Smith H. M., Turner A. F., Appl. Opt., 1965, 4(1), 147CrossRefGoogle Scholar
  25. [25]
    Baeri P., Torrisi L., Marino N., Foti G., Appl. Surf. Sci., 1992, 54, 210CrossRefGoogle Scholar
  26. [26]
    Pereiro I., Rodriguez-Valencia C., Serra C., Solla E. L., Serra J., Gonzalez P., Appl. Surf. Sci., 2012, 258, 9192CrossRefGoogle Scholar
  27. [27]
    Rau J. V., Antoniac I., Filipescu M., Cotrut C., Fosca M., Nistor L. C., Birjega R., Dinescu M., Ceram. Int., 2018, 44, 16678CrossRefGoogle Scholar
  28. [28]
    Hidalgo-Robatto B. M., Lopez-Alvarez M., Azevedo A. S., Dorado J., Serra J., Azevedo N. F., Gonzalez P., Surf. Coat. Technol., 2018, 333, 168CrossRefGoogle Scholar
  29. [29]
    Fathyunes L., Khalil-Allafi J., Appl. Surf. Sci., 2018, 437, 122CrossRefGoogle Scholar
  30. [30]
    Sun Q. Y., Yang Y. H., Luo W. J., Zhao J. H., Zhou Y. M., International Journal of Analytical Chemistry, 2017, 2017, 1CrossRefGoogle Scholar
  31. [31]
    Leadley S. R., Davies M. C., Ribeiro C. C., Barbosa M. A., Paul A. J., Watts J. F., Biomaterials, 1997, 18(4), 311CrossRefGoogle Scholar
  32. [32]
    Fu D., Jiang Q., He F., Fu B., J. Zhejiang Univ. Sci. B, 2017, 18, 778CrossRefGoogle Scholar
  33. [33]
    Zhou J. H., Han Y., Lu S. M., Int. J. Nanomed., 2014, 9, 1243Google Scholar
  34. [34]
    Sisti K. E., de Andres M. C., Johnston D., Almeida E., GU-astaldi A. C., Oreffo R. O. C., Biochem. Biophys. Res. Commun., 2016, 473, 719CrossRefGoogle Scholar
  35. [35]
    Mihailescu I. N., Teodorescu V. S., Gyorgy E., Ristoscu C., Cristescu R., Proceedings of the 9th International Conference on Advanced Laser Technologies(ALT 01), Constanta, Romania, 2001 Google Scholar
  36. [36]
    Cleries L., Martinez E., Fernandez-Pradas J. M., Sardin C., Esteve J., Morenza J. L., Biomaterials, 2000, 21, 967CrossRefGoogle Scholar
  37. [37]
    Kim H. W., Lee H. H., Knowles J. C., J. Biomed. Mater. Res. Part A, 2006, 79A, 643Google Scholar
  38. [38]
    Ito Y., Hasuda H., Kamitakahara M., Ohtsuki C., Tanihara M., Kang I. K., Kwon O. H., J. Biosci. Bioeng., 2005, 100, 43CrossRefGoogle Scholar
  39. [39]
    Bao Q., Chen C., Wang D., Lio J., Growth Des., 2008, 8, 219CrossRefGoogle Scholar
  40. [40]
    Sygnatowicz M., Keyshar K., Tiwari A., JOM(The Journal of the Minerals, Metals & Materials Society), 2010, 62, 65CrossRefGoogle Scholar
  41. [41]
    Ball M. D., Downes S., Scotchford C. A., Antonov E. N., Bagratashvili V. N., Popov V. K., Lo W. J., Grant D. M., Biomaterials, 2001, 22, 337CrossRefGoogle Scholar

Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2019

Authors and Affiliations

  • Mengna Duan
    • 1
  • Xiaofeng Wu
    • 2
  • Long Yuan
    • 3
  • Zhiying Zhang
    • 1
  • Yan Zhang
    • 1
  • Yanmin Zhou
    • 1
    Email author
  1. 1.Hospital of StomatologyJilin UniversityChangchunP. R. China
  2. 2.State Key Laboratory of Inorganic Synthesis & Preparative ChemistryJilin UniversityChangchunP. R. China
  3. 3.Key Laboratory of Functional Materials Physics and Chemistry, Ministry of EducationJilin Normal UniversityChangchunP. R. China

Personalised recommendations