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Chemical Research in Chinese Universities

, Volume 35, Issue 2, pp 235–238 | Cite as

One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase

  • Ling Jiang
  • Wenting Ye
  • Weike SuEmail author
Article
  • 8 Downloads

Abstract

A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde, malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL) as catalyst in DMSO. This protocol is featured by mild reaction conditions, simple operation and environmental acceptability.

Keywords

Porcine pancreatic lipase Biocatalysis One-pot synthesis Higly functionalized 1,4-dihydropyridines 

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Supplementary material

40242_2019_8277_MOESM1_ESM.pdf (1.9 mb)
One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine pancreatic lipase (PPL)

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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2019

Authors and Affiliations

  1. 1.Collaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhouP. R. China

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