One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase
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A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde, malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL) as catalyst in DMSO. This protocol is featured by mild reaction conditions, simple operation and environmental acceptability.
KeywordsPorcine pancreatic lipase Biocatalysis One-pot synthesis Higly functionalized 1,4-dihydropyridines
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- Isomura S., Horigome A., Kubo K., Yoshizawa Y., Okuno Y., Okayasu M., Azumaya I., Sato Y., Chemistry Select., 2018, 3(11), 3003Google Scholar