Chemical Research in Chinese Universities

, Volume 35, Issue 2, pp 235–238 | Cite as

One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase

  • Ling Jiang
  • Wenting Ye
  • Weike SuEmail author


A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde, malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreatic lipase(PPL) as catalyst in DMSO. This protocol is featured by mild reaction conditions, simple operation and environmental acceptability.


Porcine pancreatic lipase Biocatalysis One-pot synthesis Higly functionalized 1,4-dihydropyridines 


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Supplementary material

40242_2019_8277_MOESM1_ESM.pdf (1.9 mb)
One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine pancreatic lipase (PPL)


  1. [1]
    Goto R. N., Sobral L. M., Sousa L. O., Garcia C. B., Lopes N. P., Marín-Prida J., Ochoa-Rodríguez E., Verdecia-Reyes Y., Pardo-Andreu G. L., Curti C., Leopoldino A. M., Eur. J. Pharmacol., 2018, 819, 198CrossRefGoogle Scholar
  2. [2]
    Desai N. C., Trivedi A. R., Somani H. C., Bhatt K. A., Chem. Biol. Drug Des., 2015, 86(3), 370CrossRefGoogle Scholar
  3. [3]
    Vijesh A. M., Isloor A. M., Peethambar S. K., Shivananda K. N., Arulmoli T., Isloor N. A., Eur. J. Med. Chem., 2011, 46(11), 5591CrossRefGoogle Scholar
  4. [4]
    Comins D. L., Smith E. D., Tetrahedron Lett., 2006, 47(9), 1449CrossRefGoogle Scholar
  5. [5]
    Isomura S., Horigome A., Kubo K., Yoshizawa Y., Okuno Y., Okayasu M., Azumaya I., Sato Y., Chemistry Select., 2018, 3(11), 3003Google Scholar
  6. [6]
    Rao H. S. P., Parthiban A., Org. Biomol. Chem., 2014, 12(32), 6223CrossRefGoogle Scholar
  7. [7]
    Hajiyeva K., Ismiev A., Franz M., Schmidtmann M., Martens J., Maharramov A., Synth. Commun., 2017, 47(22), 2031CrossRefGoogle Scholar
  8. [8]
    Miao Y. F., Rahimi M., Geertsema E. M., Poelarends G. J., Curr. Opin. Chem. Biol., 2015, 25, 115CrossRefGoogle Scholar
  9. [9]
    Birolli W. G., Fonseca L. P., Porto A. L. M., Catal. Lett., 2017, 147(8), 1977CrossRefGoogle Scholar
  10. [10]
    Tian X. M., Zhang S. Q., Zheng L. Y., Enzyme Microb. Technol., 2016, 84, 32CrossRefGoogle Scholar
  11. [11]
    Zhang M. J., Li R., He Y. H., Guan Z., Catal. Commun., 2017, 98, 85CrossRefGoogle Scholar
  12. [12]
    Liang Y. R., Hu Y. J., Zhou X. H., Wu Q., Lin X. F., Tetrahedron Lett., 2017, 58(30), 2923CrossRefGoogle Scholar
  13. [13]
    Bihani M., Bora P. P., Verma A. K., Baruah R., Boruah H. P. D., Bez G., Bioorg. Med. Chem. Lett., 2015, 25(24), 5732CrossRefGoogle Scholar
  14. [14]
    Tang X. L., Liu J., Wang B., Yu H. W., World J. Microbiol. Biotechnol., 2011, 27(1), 129CrossRefGoogle Scholar

Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2019

Authors and Affiliations

  1. 1.Collaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhouP. R. China

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