Application of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives

  • Ling Jiang
  • Wenting Ye
  • Weike Su
  • Chuanming YuEmail author


A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, methyl acetoacetate and ethyl 3-aminocrotonate was developed. Operational simplicity, mild reaction conditions and eco-friendliness are the key features of this protocol.


Papain Catalytic promiscuity Multicomponent reaction 1,4-Dihydropyridine calcium channel antagonist 


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Application of enzymatic promiscuity in pharmaceutical synthesis: papain-catalyzed one-pot synthesis of 1,4-dihydropyridine calcium channel antagonists and derivatives


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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Ling Jiang
    • 1
    • 2
  • Wenting Ye
    • 2
  • Weike Su
    • 1
    • 2
  • Chuanming Yu
    • 2
    Email author
  1. 1.Collaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhouP. R. China
  2. 2.Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical SciencesZhejiang University of TechnologyHangzhouP. R. China

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