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Chemical Research in Chinese Universities

, Volume 34, Issue 6, pp 918–922 | Cite as

One-step Construction of Xanthone Scaffold Assisted by Microwave Irradiation to Optimize the Synthesis of DMXAA

  • Zhenlei Jiang
  • Jie Liu
  • Fan Zhou
  • Jianrun Zhang
  • Zhijun Liu
  • Chao Zhang
  • Heru ChenEmail author
Article
  • 17 Downloads

Abstract

An efficient and concise synthesis of 5,6-dimethylxanthenone-4-acetic acid(DMXAA) was developed. The overall yield of this 3-step procedure was 82%. The key reaction is the one-step construction of xanthone scaffold between 2,5-dibromo-3,4-dimethylbenzoic acid and 2-hydroxyphenyl-acetic acid assisted by microwave irradiation.

Keywords

5,6-Dimethylxanthenone-4-acetic acid Xanthone Microwave irradiation Anti-cancer 

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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Zhenlei Jiang
    • 1
  • Jie Liu
    • 1
    • 2
  • Fan Zhou
    • 1
  • Jianrun Zhang
    • 1
  • Zhijun Liu
    • 1
  • Chao Zhang
    • 1
  • Heru Chen
    • 1
    • 3
    Email author
  1. 1.Institute of Traditional Chinese Medicine and Natural Products, College of PharmacyJinan UniversityGuangzhouP. R. China
  2. 2.Department of AllergyThe Third Affiliated Hospital of Shenzhen UniversityShenzhenP. R. China
  3. 3.Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchGuangzhouP. R. China

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