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Chemical Research in Chinese Universities

, Volume 34, Issue 6, pp 1041–1050 | Cite as

pH-Responsive Polycarbonate Copolymer-based Nanoparticles for Targeted Anticancer Drug Delivery

  • Yunxia Li
  • Wenjuan Du
  • Zhiguang Fu
  • Huanhuan Wang
  • Jiexin Wang
  • Yuan Le
  • Jianjun Zhang
  • Ning Wen
Article
  • 15 Downloads

Abstract

A smart polycarbonate(PCA) copolymer-based nanoparticle(NanoPCA) with pH-responsive, long-term stability, and tumor targeting ability was successfully developed by synthesizing and assembling a series of functional PCA-based copolymers including poly(2-amino-1,3-propanediol carbonate-co-L-lactide)[P(CA-co-LA)], poly(2-amino-1,3-propanediol carbonate-co-L-lactide)-g-methoxy-poly(ethylene glycol)[P(CA-co-LA)-g-MPEG], and poly(2-amino-1,3-propanediol carbonate-co-L-lactide)-g-poly(ethylene glycol)-cyclic(Arg-Gly-Asp-D-Phe-Lys) [P(CA-co-LA)-g-PEG-cRGD] for targeted anticancer drug delivery. pH-Responsive studies demonstrated that the loading doxorubicin(DOX) released faster from NanoPCA at acidic conditions due to protonation effects of P(CA-co-LA) copolymers. Furthermore, the in vitro and in vivo investigations demonstrate that the DOX-loaded NanoPCA exhibited significant tumor targeting ability, outstanding antitumor effect and excellent biological safety in the treatment of oral squamous cell carcinoma(OSCC). Therefore, this work provides a promising drug delivery platform for cancer therapy and other applications.

Keywords

Polycarbonate copolymer-based nanoparticle(NanoPCA) pH-Responsive Tumor targeting ability Oral squamous cell carcinoma(OSCC) 

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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Yunxia Li
    • 1
  • Wenjuan Du
    • 2
  • Zhiguang Fu
    • 1
  • Huanhuan Wang
    • 1
  • Jiexin Wang
    • 3
  • Yuan Le
    • 3
  • Jianjun Zhang
    • 3
  • Ning Wen
    • 1
  1. 1.Department of Stomatologythe General Hospital of Chinese PLABeijingP. R. China
  2. 2.Department of Oncologythe General Hospital of Chinese PLABeijingP. R. China
  3. 3.College of Chemical EngineeringBeijing University of Chemical TechnologyBeijingP. R. China

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