Chemical Research in Chinese Universities

, Volume 34, Issue 5, pp 732–735 | Cite as

Structure and Activity of a New Sapogenin from Chlorophytum laxum R. Br.

  • Chenliang Chu
  • Ting Cui
  • Sida Li
  • Ruoting Zhan
  • Youheng GaoEmail author


A new steroidal sapogenin named 25-R-spirosta-3,5-dien-12β-ol(1) was isolated from the dried roots of Chlorophytum laxum R. Br. along with five known compounds, namely, diosgenin(2), stigmasterol(3), β-sitosterols(4), estigmasterol-3-O-β-D-glicopyranoside(5) and 3-O-β-authemisol(6). The structure of compound 1 was elucidated by the analysis of IR, HRESI-MS, 1D and 2D NMR spectral data. Compounds 25 were isolated from Chlorophytum laxum R. Br. In addition, all the compounds were evaluated for cytotoxicity on the human nasopharyngeal carcinoma cancer cell line 5-8F. Among them, the newly identified 25-R-spirosta-3,5-dien-12β-ol(1) and diosgenin(2) exhibited high cytotoxicity on 5-8F cells, with IC50 values of 24.8 and 41.9 μmol/L, respectively.


Chlorophytum laxum R. Br. Steroidal sapogenin Cytotoxicity 


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We gratefully acknowledge the support from Dr. PAN Chaomei of Department of Traditional Chinese Medicine Resource Center, Guangzhou University of Chinese Medicine (China).


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Copyright information

© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Chenliang Chu
    • 1
  • Ting Cui
    • 1
  • Sida Li
    • 1
  • Ruoting Zhan
    • 1
  • Youheng Gao
    • 1
    Email author
  1. 1.School of Pharmaceutical SciencesGuangzhou University of Chinese MedicineGuangzhouP. R. China

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