Advertisement

Effect of selenium supplementation on glycemic indices: a meta-analysis of randomized controlled trials

  • Armita Mahdavi Gorabi
  • Motahareh Hasani
  • Shirin Djalalinia
  • Maryam Zarei
  • Hanieh Ejtahed
  • Mohammad Esmaeili Abdar
  • Hamid Asayesh
  • Mehdi Azimzadeh
  • Mostafa QorbaniEmail author
  • Mehdi NorooziEmail author
Research article

Abstract

Purpose

The association between selenium supplementation and glycemic indices seems to be a controversial issue. This systematic review and meta-analysis was conducted to evaluate the effect of selenium supplementation on glycemic indices.

Methods

We systematically searched PubMed/MEDLINE, ISI/WOS, and Scopus (from their commencements up to Jan 2016) for relevant studies examining the association between intake of selenium and glycemic indices. The data were extracted from relevant qualified studies and estimated using the random-effect or pooled model and standardized mean difference (SMD) with 95% confidence interval (CI).

Results

Twelve articles published between 2004 and 2016 were included. In all the studies, the participants were randomly assigned to an intervention group (n = 757) or a control group(n = 684). All the studies were double blind, placebo controlled trials. Selenium supplementation resulted in a significant decrease in homeostasis model of assessment-estimated β-cell function (HOMA-B) (SMD: -0.63; 95%CI: −0.89 to −0.38) and a significant increase in quantitative insulin sensitivity check index (QUICKI) (SMD: by 0.74; 95%CI: 0.49 to 0.1) as compared with the controls. There were no statistically significant improvements in glycemic indices, such as fasting plasma glucose (FPG), insulin, homeostasis model of assessment-estimated insulin resistance (HOMA-IR), Hemoglobin A1c (HbA1c) and adiponectin.

Conclusion

This meta-analysis indicated that selenium supplementation significantly decreased HOMA-B and increased QUICKI score. There was no statistically significant improvement in FPG, insulin, HOMA-IR, HbA1c and adiponectin indices following selenium supplementation.

Keywords

Selenium Glycemic indices FPG Insulin HbA1c 

Notes

Acknowledgements

This study was funded by Alborz University of Medical Sciences. The authors are thankful of Emam Ali clinical research development unit for their assistance.

Compliance with ethical standards

Conflict of interest

None.

References

  1. 1.
    Duntas LH, Benvenga S. Selenium: an element for life. Endocrine. 2015;48(3):756–75.CrossRefGoogle Scholar
  2. 2.
    Carlson BA, Yoo M-H, Shrimali RK, Irons R, Gladyshev VN, Hatfield DL, et al. Role of selenium-containing proteins in T-cell and macrophage function. Proc Nutr Soc. 2010;69(3):300–10.CrossRefGoogle Scholar
  3. 3.
    LH D. Selenium and inflammation: underlying anti-inflammatory mechanisms. Horm Metab Res. 2009;41(06):443–7.CrossRefGoogle Scholar
  4. 4.
    Hatfield DL, Gladyshev VN. The outcome of selenium and vitamin E Cancer prevention trial (SELECT) reveals the need for better understanding of selenium biology. Mol Interv. 2009;9(1):18–21.CrossRefGoogle Scholar
  5. 5.
    Hoffmann FKW, Hashimoto AC, Shafer LA, Dow S, Berry MJ, Hoffmann PR. Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols. J Nutr. 2010;140(6):1155–61.CrossRefGoogle Scholar
  6. 6.
    Diplock AT. Antioxidants and disease prevention. Mol Asp Med. 1994;15(4):293–376.CrossRefGoogle Scholar
  7. 7.
    Nève J. Selenium as a risk factor for cardiovascular diseases. J Cardiovasc Risk. 1996;3(1):42–7.CrossRefGoogle Scholar
  8. 8.
    Liu R, Xia L, Zhuoya Z, Min Z, Yue S, Dinglei S, et al. Allogeneic mesenchymal stem cells inhibited T follicular helper cell generation in rheumatoid arthritis. Sci Rep. 2015;5:12777.CrossRefGoogle Scholar
  9. 9.
    Fasano E, Serini S, Mondella N, Trombino S, Celleno L, Lanza P, et al. Antioxidant and anti-inflammatory effects of selected natural compounds contained in a dietary supplement on two human immortalized keratinocyte lines. Biomed Res Int. 2014;2014:1–11.CrossRefGoogle Scholar
  10. 10.
    Wang C, Yang S, Zhang N, Mu Y, Ren H, Wang Y, et al. Long-term supranutritional supplementation with selenate decreases hyperglycemia and promotes fatty liver degeneration by inducing hyperinsulinemia in diabetic db/db mice. PLoS One. 2014;9(7):e101315.CrossRefGoogle Scholar
  11. 11.
    Campbell SC, Aldibbiat A, Marriott CE, Landy C, Ali T, Ferris WF, et al. Selenium stimulates pancreatic beta-cell gene expression and enhances islet function. FEBS Lett. 2008;582(15):2333–7.CrossRefGoogle Scholar
  12. 12.
    Stranges S, Ana N-A, Rayman MP, Eliseo G. Selenium status and cardiometabolic health: state of the evidence. Nutr Metab Cardiovasc Dis. 2010;20(10):754–60.CrossRefGoogle Scholar
  13. 13.
    Stranges S, Marshall James R, Raj N, Donahue Richard P, Maurizio T, Combs Gerald F, et al. Effects of long-term selenium supplementation on the incidence of type 2 DiabetesA randomized TrialSelenium supplementation and risk for type 2 diabetes. Ann Intern Med. 2007a;147(4):217–23.CrossRefGoogle Scholar
  14. 14.
    Lippman SM, Klein Eric A, Goodman Phyllis J, Scott LM, Thompson Ian M, Ford Leslie G, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E Cancer prevention trial (SELECT). Jama. 2009;301(1):39–51.CrossRefGoogle Scholar
  15. 15.
    Zhou J, Huang K, Lei XG. Selenium and diabetes—evidence from animal studies. Free Radic Biol Med. 2013;65:1548–56.CrossRefGoogle Scholar
  16. 16.
    Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.CrossRefGoogle Scholar
  17. 17.
    Nikuei P, Nahid D, Iman T, Ali KA. Predictive value of miR-210 as a novel biomarker for pre-eclampsia: a systematic review protocol. BMJ Open. 2016;6(9):e011920.CrossRefGoogle Scholar
  18. 18.
    Khosravi M, Djalalinia S, Hasani M, Saeedi Moghaddam S, Kazemzadeh Atoofi M, Asayesh H, et al. Effects of selenium supplementation on cardiometabolic risk factors, inflammatory factors and antioxidant factors : a systematic review and meta-analysis protocol. IJPM. 2017; (Submitted).Google Scholar
  19. 19.
    Hozo SP, Benjamin D, Iztok H. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005;5(1):13.CrossRefGoogle Scholar
  20. 20.
    DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177–88.CrossRefGoogle Scholar
  21. 21.
    Whitehead A, Whitehead J. A general parametric approach to the meta-analysis of randomized clinical trials. Stat Med. 1991;10(11):1665–77.CrossRefGoogle Scholar
  22. 22.
    Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–60.CrossRefGoogle Scholar
  23. 23.
    Intercooled Stata. 8.0 for windows. College Station, TX: Stata Corp; 2003. 2007.Google Scholar
  24. 24.
    Alizadeh M, Safaeiyan A, Ostadrahimi A, Estakhri R, Daneghian S, Ghaffari A, et al. Effect of L-arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: a randomized, double-blind, placebo-controlled trial. Ann Nutr Metab. 2012;60(2):157–68.CrossRefGoogle Scholar
  25. 25.
    Asemi Z, Jamilian M, Mesdaghinia E, Esmaillzadeh A. Effects of selenium supplementation on glucose homeostasis, inflammation, and oxidative stress in gestational diabetes: randomized, double-blind, placebo-controlled trial. Nutrition. 2015;31(10):1235–42.CrossRefGoogle Scholar
  26. 26.
    Bahmani F, Kia M, Soleimani A, Asemi Z, Esmaillzadeh A. Effect of selenium supplementation on glycemic control and lipid profiles in patients with diabetic nephropathy. Biol Trace Elem Res. 2016;172(2):282–9.CrossRefGoogle Scholar
  27. 27.
    Faghihi T, Radfar M, Barmal M, Amini P, Qorbani M, Abdollahi M, et al. A randomized, placebo-controlled trial of selenium supplementation in patients with type 2 diabetes: effects on glucose homeostasis, oxidative stress, and lipid profile. Am J Ther. 2014;21(6):491–5.CrossRefGoogle Scholar
  28. 28.
    Farrokhian A, Bahmani F, Taghizadeh M, Mirhashemi SM, Aarabi MH, Raygan F, et al. Selenium supplementation affects insulin resistance and serum hs-CRP in patients with type 2 diabetes and coronary heart disease. Horm Metab Res. 2016a;48(04):263–8.CrossRefGoogle Scholar
  29. 29.
    Faure P, Ramon O, Favier A, Halimi S. Selenium supplementation decreases nuclear factor-kappa B activity in peripheral blood mononuclear cells from type 2 diabetic patients. Eur J Clin Investig. 2004;34(7):475–81.CrossRefGoogle Scholar
  30. 30.
    Jamilian M, Razavi M, Fakhrie Kashan Z, Ghandi Y, Bagherian T, Asemi Z. Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol. 2015;82(6):885–91.CrossRefGoogle Scholar
  31. 31.
    Mao J, Bath SC, Vanderlelie JJ, Perkins AV, Redman CWG, Rayman MP. No effect of modest selenium supplementation on insulin resistance in UK pregnant women, as assessed by plasma adiponectin concentration. Br J Nutr. 2016;115(1):32–8.CrossRefGoogle Scholar
  32. 32.
    Murer SB, Aeberli I, Braegger CP, Gittermann M, Hersberger M, Leonard SW, et al. Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents. J Nutr. 2014;144(2):193–201.CrossRefGoogle Scholar
  33. 33.
    Rayman MP, Blundell-Pound G, Pastor-Barriuso R, Guallar E, Steinbrenner H, Stranges S. A randomized trial of selenium supplementation and risk of type-2 diabetes, as assessed by plasma adiponectin. PLoS One. 2012;7(9):e45269.CrossRefGoogle Scholar
  34. 34.
    Shargorodsky M, Debby O, Matas Z, Zimlichman R. Effect of long-term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors. Nutr Metab (Lond). 2010;7:55.CrossRefGoogle Scholar
  35. 35.
    Mohammad Hosseinzadeh F, Hosseinzadeh-Attar MJ, Yekaninejad MS, Rashidi B. Effects of selenium supplementation on glucose homeostasis and free androgen index in women with polycystic ovary syndrome: a randomized, double blinded, placebo controlled clinical trial. J Trace Elem Med Biol. 2016;34:56–61.CrossRefGoogle Scholar
  36. 36.
    Algotar AM, Stratton MS, Stratton SP, Hsu C-H, Ahmann FR. No effect of selenium supplementation on serum glucose levels in men with prostate cancer. Am J Med. 2010;123(8):765–8.CrossRefGoogle Scholar
  37. 37.
    Stranges S, Marshall James R, Raj N, Donahue Richard P, Maurizio T, Combs Gerald F, et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med. 2007b;147(4):217–23.CrossRefGoogle Scholar
  38. 38.
    Vinceti M, Filippini T, Rothman KJ. Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. Springer. 2018.Google Scholar
  39. 39.
    Kohler L, Janet F, Connor K, Ana F, Colleen S, Chow HH, et al. Selenium and Type 2 Diabetes: Systematic Review. Nutrients. 2018;10(12):1924.CrossRefGoogle Scholar
  40. 40.
    Farrokhian A, Bahmani F, Taghizadeh M, Mirhashemi SM, Aarabi MH, Raygan F, et al. Research metabolic. Selenium supplementation affects insulin resistance and serum hs-CRP in patients with type 2 diabetes and coronary. Heart Dis. 2016b;48(04):263–8.Google Scholar
  41. 41.
    Barman S, Krishnapura S. Zinc supplementation alleviates hyperglycemia and associated metabolic abnormalities in streptozotocin-induced diabetic rats. Can J Physiol Pharmacol. 2016;94(12):1356–65.CrossRefGoogle Scholar
  42. 42.
    Tabrizi R, Maryam A, Mahmood M, Lankarani Kamran B, Taghi HS, Fariba K, et al. The effects of selenium supplementation on glucose metabolism and lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Horm Metab Res. 2017;49(11):826–30.CrossRefGoogle Scholar
  43. 43.
    Katsuki A, Yasuhiro S, Gabazza Esteban C, Shuichi M, Masahiko F, Rika A-S, et al. Homeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes. Diabetes Care. 2001;24(2):362–5.CrossRefGoogle Scholar
  44. 44.
    W J, Li X, Li Z, Wu GR, Fu XF, Yang XM, et al. The effect of selenium supplementation on coronary heart disease: a systematic review and meta-analysis of randomized controlled trials. J Trace Elem Med Biol. 2017;44:8–16.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Armita Mahdavi Gorabi
    • 1
  • Motahareh Hasani
    • 2
  • Shirin Djalalinia
    • 3
    • 4
  • Maryam Zarei
    • 5
  • Hanieh Ejtahed
    • 6
  • Mohammad Esmaeili Abdar
    • 7
  • Hamid Asayesh
    • 8
  • Mehdi Azimzadeh
    • 7
  • Mostafa Qorbani
    • 7
    • 9
    Email author
  • Mehdi Noroozi
    • 10
    Email author
  1. 1.Department of Basic and Clinical Research, Tehran Heart CenterTehran University of Medical SciencesTehranIran
  2. 2.School of Public HealthIran University of Medical SciencesTehranIran
  3. 3.Development of Research & Technology CenterDeputy of Research and Technology, Ministry of Health and Medical EducationTehranIran
  4. 4.Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences InstituteTehran University of Medical SciencesTehranIran
  5. 5.Department of Nutrition and Dietetics, Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdangMalaysia
  6. 6.Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  7. 7.Non-communicable Diseases Research CenterAlborz University of Medical SciencesKarajIran
  8. 8.Department of Medical EmergenciesQom University of Medical SciencesQomIran
  9. 9.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran
  10. 10.Social Determinants of Health Research CenterUniversity of Social Welfare and Rehabilitation SciencesTehranIran

Personalised recommendations