Effect of selenium supplementation on glycemic indices: a meta-analysis of randomized controlled trials

  • Armita Mahdavi Gorabi
  • Motahareh Hasani
  • Shirin Djalalinia
  • Maryam Zarei
  • Hanieh Ejtahed
  • Mohammad Esmaeili Abdar
  • Hamid Asayesh
  • Mehdi Azimzadeh
  • Mostafa QorbaniEmail author
  • Mehdi NorooziEmail author
Research article



The association between selenium supplementation and glycemic indices seems to be a controversial issue. This systematic review and meta-analysis was conducted to evaluate the effect of selenium supplementation on glycemic indices.


We systematically searched PubMed/MEDLINE, ISI/WOS, and Scopus (from their commencements up to Jan 2016) for relevant studies examining the association between intake of selenium and glycemic indices. The data were extracted from relevant qualified studies and estimated using the random-effect or pooled model and standardized mean difference (SMD) with 95% confidence interval (CI).


Twelve articles published between 2004 and 2016 were included. In all the studies, the participants were randomly assigned to an intervention group (n = 757) or a control group(n = 684). All the studies were double blind, placebo controlled trials. Selenium supplementation resulted in a significant decrease in homeostasis model of assessment-estimated β-cell function (HOMA-B) (SMD: -0.63; 95%CI: −0.89 to −0.38) and a significant increase in quantitative insulin sensitivity check index (QUICKI) (SMD: by 0.74; 95%CI: 0.49 to 0.1) as compared with the controls. There were no statistically significant improvements in glycemic indices, such as fasting plasma glucose (FPG), insulin, homeostasis model of assessment-estimated insulin resistance (HOMA-IR), Hemoglobin A1c (HbA1c) and adiponectin.


This meta-analysis indicated that selenium supplementation significantly decreased HOMA-B and increased QUICKI score. There was no statistically significant improvement in FPG, insulin, HOMA-IR, HbA1c and adiponectin indices following selenium supplementation.


Selenium Glycemic indices FPG Insulin HbA1c 



This study was funded by Alborz University of Medical Sciences. The authors are thankful of Emam Ali clinical research development unit for their assistance.

Compliance with ethical standards

Conflict of interest



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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Armita Mahdavi Gorabi
    • 1
  • Motahareh Hasani
    • 2
  • Shirin Djalalinia
    • 3
    • 4
  • Maryam Zarei
    • 5
  • Hanieh Ejtahed
    • 6
  • Mohammad Esmaeili Abdar
    • 7
  • Hamid Asayesh
    • 8
  • Mehdi Azimzadeh
    • 7
  • Mostafa Qorbani
    • 7
    • 9
    Email author
  • Mehdi Noroozi
    • 10
    Email author
  1. 1.Department of Basic and Clinical Research, Tehran Heart CenterTehran University of Medical SciencesTehranIran
  2. 2.School of Public HealthIran University of Medical SciencesTehranIran
  3. 3.Development of Research & Technology CenterDeputy of Research and Technology, Ministry of Health and Medical EducationTehranIran
  4. 4.Non-communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences InstituteTehran University of Medical SciencesTehranIran
  5. 5.Department of Nutrition and Dietetics, Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdangMalaysia
  6. 6.Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  7. 7.Non-communicable Diseases Research CenterAlborz University of Medical SciencesKarajIran
  8. 8.Department of Medical EmergenciesQom University of Medical SciencesQomIran
  9. 9.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran
  10. 10.Social Determinants of Health Research CenterUniversity of Social Welfare and Rehabilitation SciencesTehranIran

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