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Natural polyphenols for the prevention of irritable bowel syndrome: molecular mechanisms and targets; a comprehensive review

  • Nazanin Momeni Roudsari
  • Naser-Aldin Lashgari
  • Saeideh Momtaz
  • Mohammad Hosein FarzaeiEmail author
  • André M. Marques
  • Amir Hossein AbdolghaffariEmail author
Review article

Abstract

Irritable bowel syndrome (IBS) is a well diagnosed disease, thoroughly attributed to series of symptoms criteria that embrace a broad range of abdominal complainers. Such criteria help to diagnosis the disease and can guide controlled clinical trials to seek new therapeutic agents. Accordingly, a verity of mechanisms and pathophysiological conditions including inflammation, oxidative stress, lipid peroxidation and different life styles are involved in IBS. Predictably, diverse therapeutic approaches are available and prescribed by clinicians due to major manifestations (i.e., diarrhea-predominance, constipation-predominance, abdominal pain and visceral hypersensitivity), psychological disturbances, and patient preferences between herbal treatments versus pharmacological therapies, dietary or microbiological approaches. Herein, we gathered the latest scientific data between 1973 and 2019 from databases such as PubMed, Google Scholar, Scopus and Cochrane library on relevant studies concerning beneficial effects of herbal treatments for IBS, in particular polyphenols. This is concluded that polyphenols might be applicable for preventing IBS and improving the IBS symptoms, mainly through suppressing the inflammatory signaling pathways, which nowadays are known as novel platform for the IBS management.

Keywords

Gastroenterology Irritable bowel syndrome Mechanism Inflammation and oxidative stress Herbal therapy Polyphenols 

Notes

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Nazanin Momeni Roudsari
    • 1
  • Naser-Aldin Lashgari
    • 1
  • Saeideh Momtaz
    • 2
    • 3
    • 4
  • Mohammad Hosein Farzaei
    • 5
    • 6
    Email author
  • André M. Marques
    • 7
  • Amir Hossein Abdolghaffari
    • 1
    • 2
    • 3
    • 4
    • 8
    Email author
  1. 1.Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences BranchIslamic Azad UniversityTehranIran
  2. 2.Medicinal Plants Research CenterInstitute of Medicinal Plants, ACECRKarajIran
  3. 3.Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS)Tehran University of Medical SciencesTehranIran
  4. 4.Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran
  5. 5.Pharmaceutical Sciences Research Center, Health InstituteKermanshah University of Medical SciencesKermanshahIran
  6. 6.Medical Biology Research CenterKermanshah University of Medical SciencesKermanshahIran
  7. 7.Oswaldo Cruz Foundation (FIOCRUZ)Institute of Technology in Pharmaceuticals (Farmanguinhos)Rio de JaneiroBrazil
  8. 8.Gastrointestinal Pharmacology Interest Group (GPIG)Universal Scientific Education and Research Network (USERN)TehranIran

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