DARU Journal of Pharmaceutical Sciences

, Volume 26, Issue 2, pp 229–239 | Cite as

A systematic review of nano formulation of natural products for the treatment of inflammatory bowel disease: drug delivery and pharmacological targets

  • Yasamin Davatgaran Taghipour
  • Roodabeh Bahramsoltani
  • André M. Marques
  • Rozita Naseri
  • Roja Rahimi
  • Pouya Haratipour
  • Amin Iran Panah
  • Mohammad Hosein FarzaeiEmail author
  • Mohammad Abdollahi
Review Article


Inflammatory bowel diseases (IBD), which is classified into Crohn’s disease and ulcerative colitis, are among chronic gastrointestinal diseases with unknown pathogenesis. Diverse strategies have been applied for the treatment of this chronic disease. However, selective and site-specific routes of drug delivery to the inflamed location of the colon remain of high importance. Consequently, the application and effects of natural products in the form of nanoformulation and stimuli responsive nanoparticles as a novel strategy for the treatment of IBD are discussed in this review article. This approach may potentially overcome some complications that are associated with conventional means of colon drug delivery. Meanwhile, in vitro and in vivo studies pave the way for understanding of the mechanism that lies behind this chronic relapsing disease and potentially more effective treatment.

Graphical abstract


Inflammatory bowel disease Natural nanoformulation Stimuli responsive nanoparticles Crohn’s disease Ulcerative colitis 


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Yasamin Davatgaran Taghipour
    • 1
    • 2
    • 3
  • Roodabeh Bahramsoltani
    • 2
    • 4
  • André M. Marques
    • 5
  • Rozita Naseri
    • 6
  • Roja Rahimi
    • 4
  • Pouya Haratipour
    • 7
    • 8
  • Amin Iran Panah
    • 9
  • Mohammad Hosein Farzaei
    • 10
    • 11
    Email author
  • Mohammad Abdollahi
    • 12
    • 13
  1. 1.Department of Medical Nanotechnology, School of Advanced Medical SciencesTabriz University of Medical SciencesTabrizIran
  2. 2.PhytoPharmacology Interest Group (PPIG)Universal Scientific Education and Research Network (USERN)TehranIran
  3. 3.Student Research CommitteeTabriz University of Medical SciencesTabrizIran
  4. 4.Department of Pharmacy in Persian Medicine, School of Persian MedicineTehran University of Medical SciencesTehranIran
  5. 5.Oswaldo Cruz Foundation (FIOCRUZ)Institute of Technology in Pharmaceuticals (Farmanguinhos)Rio de JaneiroBrazil
  6. 6.Internal Medicine Department, Faculty of MedicineKermanshah University of Medical SciencesKermanshahIran
  7. 7.Department of ChemistrySharif University of TechnologyTehranIran
  8. 8.PhytoPharmacology Interest Group (PPIG)Universal Scientific Education and Research Network (USERN)Los AngelesUSA
  9. 9.Faculty of PharmacyKermanshah University of Medical SciencesKermanshahIran
  10. 10.Pharmaceutical Sciences Research CenterKermanshah University of Medical SciencesKermanshahIran
  11. 11.Medical Biology Research CenterKermanshah University of Medical SciencesKermanshahIran
  12. 12.Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS)Tehran University of Medical SciencesTehranIran
  13. 13.Department of Toxicology and Pharmacology, Faculty of PharmacyTehran University of Medical SciencesTehranIran

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