Perioperative Developments in Biliary Atresia Treatment
Purpose of Review
This paper presents an overview of the current developments in the perioperative biliary atresia (BA) treatment.
Biliary atresia is a rare cholangiopathy and the most common indication for pediatric liver transplantation. Kasai portoenterostomy is the primary therapy, leading to sufficient biliary drainage in 20–30% of patients with native liver. Multiple strategies in preoperative, operative, and postoperative care were tested to improve survival with native liver (SNL). Screening methods, centralization of care to specialized centers, laparoscopic Kasai procedure, and adjuvant steroid therapies are suggested to improve the operative outcomes.
There is no evident superiority of laparoscopic KPE nor adjuvant steroid therapy. However, screening programs and centralization of care to specialized centers are endorsed.
KeywordsBiliary atresia Kasai portoenterostomy Screening Centralization Laparoscopic Kasai
Biliary atresia and related disorders
Childhood Liver Disease Research and Education Network
European Reference Networks
Jaundice-free survival with native liver
Survival with native liver
Steroids in Biliary Atresia Randomized Trial
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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