Pathophysiology of Complex Regional Pain Syndrome and Treatment: Recent Advancements

  • Sarah MoneyEmail author
Pain Management (S Mace, Section Editor)
Part of the following topical collections:
  1. Pain Management


Purpose of Review

Complex regional pain syndrome (CRPS) is a painful and debilitating disorder involving dysfunction in multiple body systems. This review seeks to evaluate recent data and present treatment options for the practical management of this condition.

Recent Findings

The mechanism by which CRPS develops is multifactorial, affecting both the peripheral and central nervous systems, and nerve changes can be seen at a histologic level. Treatment should be initiated as early as possible, as the chronic disease is less responsive to intervention.


CRPS is a clinical diagnosis; treatment is symptomatic and aimed at addressing the sensory, vasomotor, sudomotor, and trophic changes which occur in the context of severe pain. Management may include therapy, oral or intravenous medication, procedures, or surgery.


Sympathetic pain Complex regional pain syndrome CRPS CRPS management Reflex sympathetic dystrophy Causalgia 


Compliance with Ethical Standards

Conflict of Interest

The author declares that she has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Anesthesiology, Pain Management, and Perioperative MedicineHenry Ford HospitalDetroitUSA

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