Necrotizing Soft Tissue Infections

  • B. Bryan GrahamEmail author
Infectious Disease (J Glauser, Section Editor)
Part of the following topical collections:
  1. Infectious Disease


Purpose of Review

The review discusses necrotizing soft tissue infections, including clinical manifestations, diagnosis and management.

Recent Findings

There has been an effort towards developing scoring systems to aid in the diagnosis of necrotizing soft tissue infections and this article reviews those in addition to their applicability. These scoring systems should primarily be used to aid in diagnosis and are not effective at ruling out necrotizing infections. Recent reviews regarding optimal antibiotics and IVIG are also discussed.


Necrotizing soft tissue infections are challenging to diagnosis as they often mimic more benign conditions. A high clinical suspicion should be maintained to diagnose this disease process. Broad-spectrum antibiotics and surgical debridement are required for management. The mortality from these infections is high and patients will often be critically ill. Prompt diagnosis, resuscitation, and definitive therapy are keys to improvements in patient morbidity and mortality.


Necrotizing soft tissue infection Necrotizing infections Necrotizing fasciitis Soft tissue infections 


Compliance with Ethical Standards

Conflict of Interest

B. Bryan Graham declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Cleveland ClinicClevelandUSA

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