Review of the Evidence for Topical Nonsteroidal Anti-inflammatory Drugs Post-cataract Surgery

  • Todd UrtonEmail author
  • Jessica Ruzicki
Cataract (CE Starr and A Brissette, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Cataract


Purpose of Review

In this article, we review the recent literature surrounding the use of topical nonsteroidal anti-inflammatory drops for prophylaxis of cystoid macular edema following uncomplicated cataract surgery.

Recent Findings

As has been found with past research, most recent studies suggest that topical NSAIDs may help reduce the incidence of postoperative cystoid macular edema. The effect may be minimal in patients at low risk for macular edema, and more pronounced in those at high risk. The evidence suggests that the effect is maximized when used in combination with topical corticosteroids.


Although there remain several limitations to the research on this topic that restrict our ability to draw firm conclusions, the bulk of the evidence supports the use of postoperative topical NSAIDs for cataract surgery in patients at high risk for macular edema. However there is no consensus regarding the ideal choice of NSAID, or the ideal dosing regimen following surgery.


Nonsteroidal anti-inflammatory Cystoid macular edema Cataract surgery OCT 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of OphthalmologyQueen’s UniversityKingstonCanada

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