Current Ophthalmology Reports

, Volume 7, Issue 1, pp 37–44 | Cite as

New Insights Into Corneal Endothelial Regeneration

  • Mansab Jafri
  • Kathryn ColbyEmail author
Regenerative Medicine in Ophthalmology (D Myung, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Ocular Microbiology and Immunology


Purpose of Review

This article reviews our current understanding of the regenerative capacity of the corneal endothelium and critically evaluates new and important research in the treatment of endothelial dysfunction.

Recent Findings

The development and application of new surgical (Descemet’s membrane stripping only), pharmacologic (rho kinase inhibitors, such as ripasudil), and injectable cell culture modalities for the treatment of endothelial dysfunction have sparked debate in the cornea world and may revolutionize future clinical practice.


The exact mechanisms involved in corneal endothelial regeneration remain elusive. The latest treatment strategies for endothelial dysfunction have the potential to transform our previous perceptions of endothelial physiology by eliciting new and exciting research questions for future investigations.


Corneal endothelial regeneration Descemet stripping only Cell culture Fuchs dystrophy Descemetorhexis Rho kinase inhibitors 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Kansas City University of Medicine and BiosciencesKansas CityUSA
  2. 2.Department of Ophthalmology and Visual ScienceUniversity of ChicagoChicagoUSA

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