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Current Ophthalmology Reports

, Volume 7, Issue 1, pp 30–36 | Cite as

Updates on Corneal Xenotransplantation

  • Hyuk Jin Choi
  • Chang Ho Yoon
  • Mee Kum KimEmail author
Regenerative Medicine in Ophthalmology (D Myung, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Regenerative Medicine in Ophthalmology

Abstract

Purpose of Review

Globally, the supply of donor cornea does not meet the demand in certain regions. Corneal xenotransplantation has been investigated as an alternative option of corneal allotransplantation. This review aims to provide a comprehensive update on corneal xenotransplantation.

Recent Findings

This article reviews current knowledge of the antigenicity and bio-physical properties of pig corneal grafts in corneal xenotransplantation, including efficacy and safety data of corneal xenotransplantation using genetically engineered (GE) or wild-type (WT) porcine grafts and decellularized porcine grafts in nonhuman primates as a proof-of-concept. Recent advances in regulatory issues and standardization of protocols for their use are also discussed to help facilitate clinical trials of corneal xenotransplantation in the future.

Summary

This review posits that a proof-of-concept opportunity exists in certain breeds of pigs on corneal xenotransplantation, suggesting feasibility as an alternative option of corneal allotransplantation.

Keywords

Corneal blindness  Corneal xenotransplantation Porcine cornea 

Notes

Funding Information

This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health & Welfare, Republic of Korea (Project No. HI13C0954).

Compliance With Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Hyuk Jin Choi
    • 1
    • 2
  • Chang Ho Yoon
    • 1
    • 2
  • Mee Kum Kim
    • 1
    • 2
    Email author
  1. 1.Department of OphthalmologySeoul National University College of MedicineSeoulSouth Korea
  2. 2.Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye CenterSeoul National University Hospital Biomedical Research InstituteSeoulSouth Korea

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