Updates on Corneal Xenotransplantation
Purpose of Review
Globally, the supply of donor cornea does not meet the demand in certain regions. Corneal xenotransplantation has been investigated as an alternative option of corneal allotransplantation. This review aims to provide a comprehensive update on corneal xenotransplantation.
This article reviews current knowledge of the antigenicity and bio-physical properties of pig corneal grafts in corneal xenotransplantation, including efficacy and safety data of corneal xenotransplantation using genetically engineered (GE) or wild-type (WT) porcine grafts and decellularized porcine grafts in nonhuman primates as a proof-of-concept. Recent advances in regulatory issues and standardization of protocols for their use are also discussed to help facilitate clinical trials of corneal xenotransplantation in the future.
This review posits that a proof-of-concept opportunity exists in certain breeds of pigs on corneal xenotransplantation, suggesting feasibility as an alternative option of corneal allotransplantation.
KeywordsCorneal blindness Corneal xenotransplantation Porcine cornea
This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health & Welfare, Republic of Korea (Project No. HI13C0954).
Compliance With Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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