Current Ophthalmology Reports

, Volume 7, Issue 1, pp 1–10 | Cite as

Emerging Approaches for Ocular Surface Regeneration

  • Ghasem Yazdanpanah
  • Sayena Jabbehdari
  • Ali R. DjalilianEmail author
Regenerative Medicine in Ophthalmology (D Myung, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Regenerative Medicine in Ophthalmology


Purpose of Review

In this manuscript, the recent advancements and novel approaches for regeneration of the ocular surface are summarized.

Recent Findings

Following severe injuries, persistent inflammation can alter the rehabilitative capability of the ocular surface environment. Limbal stem cell deficiency (LSCD) is one of the most characterized ocular surface disorders mediated by deficiency and/or dysfunction of the limbal epithelial stem cells (LESCs) located in the limbal niche. Currently, the most advanced approach for revitalizing the ocular surface and limbal niche is based on transplantation of limbal tissues harboring LESCs. Emerging approaches have focused on restoring the ocular surface microenvironment using (1) cell-based therapies including cells with capabilities to support the LESCs and modulate the inflammation, e.g., mesenchymal stem cells (MSCs), (2) bioactive extracellular matrices from decellularized tissues, and/or purified/synthetic molecules to regenerate the microenvironment structure, and (3) soluble cytokine/growth factor cocktails to revive the signaling pathways.


Ocular surface/limbal environment revitalization provides promising approaches for regeneration of the ocular surface.


Ocular surface regeneration Corneal epithelium Limbal stem cell niche Limbal epithelial stem cell deficiency Extracellular matrix Mesenchymal stem cells 


Sources of Support

This research was supported by R01 EY024349 (ARD) and core grant EY01792 from NEI/NIH and unrestricted grant to the Department of Ophthalmology from Research to Prevent Blindness.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ghasem Yazdanpanah
    • 1
  • Sayena Jabbehdari
    • 1
  • Ali R. Djalilian
    • 1
    Email author
  1. 1.Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear InfirmaryUniversity of Illinois at ChicagoChicagoUSA

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