Clinical Evaluation of Glycoproteins and Inflammatory Cytokines in the Serum of Dogs Affected with Canine Mammary Cancer
- 9 Downloads
In canine mammary tumours, role of surface glycoproteins and cytokines is poorly understood as focus on these markers in the veterinary practice is lacking. The serum markers in 41 malignant CMT cases along with six control dogs were studied to determine their importance in the diagnosis and prognosis of CMT. The surface glycoproteins (CA 15.3 and CEA) and inflammatory cytokines (IL-8 and TNF-α) in mammary tumour cases were significantly higher than those of controls. The Kaplan–Meier survival analysis elucidated poor survival in cases with high serum marker levels. The studies implicate that serum glycoproteins and cytokines are important determinants of diagnosis and prognosis of this tumour having great relevance in veterinary oncology.
KeywordsCanine CA 15.3 CEA IL8 TNFα
The first author is highly grateful to DST INSPIRE, New Delhi, India, for fellowship during the Ph.D. programme (Fellowship No. IF 130347). The current research has been carried out at the Department of Veterinary Pathology, GADVASU, Ludhiana. The study is a part of the research project entitled “Canine Mammary Tumour as a Model for Human Breast Cancer” funded by ICAR Niche area of excellence.
Compliance with ethical standards
Conflict of interest
The authors declare that there is no conflict of interest to publish this manuscript.
- 1.Weichselbaumer M, Willmann M, Reifinger M, Singer J, Bajna E, Sobanov Y, Mechtcherikova D, Selzer E, Johann G, Kammerer R, Jarolim EJ (2011) Phylogenetic discordance of human and canine carcinoembryonic antigen (CEA, CEACAM) families, but striking identity of the CEA receptors will impact comparative oncology studies. PLOS Curr Tree Life. https://doi.org/10.1371/currents.rrn1223 Google Scholar
- 4.Chan YH (2004) Biostatistics 203 survival analysis. Singap Med J 45:249–256Google Scholar
- 5.Souza JV (2002) Marker mucinous cancer associated. Rev AMRIGS 46:70–83Google Scholar
- 7.Una Cidon E (2017) A brief overview of the role of CA 15.3 in breast cancer. Web Med Central Breast 8:WMC005313Google Scholar
- 8.Shawn RC, Kevin LB, Bryant SA (2002) Comparative study of four serological tumour markers for the detection of breast cancer. J Miss Acad Sci 47:126–128Google Scholar
- 9.Balint E, Manolescu N, Braslasu D (2008) Molecular detection through CEA (carcino-embrionic-antigen) of different types of cancer in animal. Lucr Stiint Med Vet 51:89–93Google Scholar
- 12.Machado VS, Leandro Z, Crivellenti BC, Nathieli B, Alexandre Luana P, Borin-Crivellentib S, Santanab AE, Vanessa D, Morescof Rafael N, Rosa C, Schetingerd VM (2015) Oxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma. Pathol Res Pract 211:677–681CrossRefGoogle Scholar
- 15.Barbieri A, Quagliariello V, Vecchio VD, Falco M, Luciano A, Amruthraj NJ, Nasti G, Ottaiano A, Berretta M, Iaffaioli RV, Arra C (2017) Anticancer and anti-inflammatory properties of ganoderma lucidum extract effects on melanoma and triple-negative breast cancer treatment. Nutrients 9:210CrossRefGoogle Scholar