Computed Distribution of Quaternary Complexes of Cu(II), Zn(II) Co(II) and Ni(II) with Citrulline and Tryphtophan as Primary Ligand and Thymine as Secondary Ligand

  • Monika Singh
  • Surabhi Sinha
  • Vijay KrishnaEmail author
Research Article


Investigation in solution exhibits the interest of chemist in thermodynamic aspects, which include knowledge of the stability constant of complexes with ligands of biochemical interest. It has been relevant for the experimental modeling of both reactions of metal ions with biomolecules and non-covalent interactions occurring in biological system. Stability constant data have been utilized to compute the equilibrium constant of ternary and quaternary complexes of citrulline/tryptophan and thymine with Cu(II), Zn(II) Co(II) and Ni(II) using SCOGS computer program at 37 ± 1 °C and in ionic strength I = 0.1 M NaNO3. The metal–ligand formation constant of MA, MB, MAB and M1M2AB type of complexes follows Irving William order. The distribution curves of various complex species occurring at the different physiological pH have been discussed, and solution structures with an explanation of plausible equilibria have been proposed.


Citrulline Tryptophan Thymine SCOGS computer program 



Authors are grateful to the UGC Rajiv Gandhi National Fellowship (JRF and SRF), New Delhi, for providing the financial assistance in completion of this research work.


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© The National Academy of Sciences, India 2019

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of AllahabadAllahabadIndia
  2. 2.Department of Applied Sciences (Chemistry)United College of Engineering & ResearchAllahabadIndia

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