Advertisement

Computed Distribution of Quaternary Complexes of Cu(II), Zn(II) Co(II) and Ni(II) with Citrulline and Tryphtophan as Primary Ligand and Thymine as Secondary Ligand

  • Monika Singh
  • Surabhi Sinha
  • Vijay KrishnaEmail author
Research Article
  • 19 Downloads

Abstract

Investigation in solution exhibits the interest of chemist in thermodynamic aspects, which include knowledge of the stability constant of complexes with ligands of biochemical interest. It has been relevant for the experimental modeling of both reactions of metal ions with biomolecules and non-covalent interactions occurring in biological system. Stability constant data have been utilized to compute the equilibrium constant of ternary and quaternary complexes of citrulline/tryptophan and thymine with Cu(II), Zn(II) Co(II) and Ni(II) using SCOGS computer program at 37 ± 1 °C and in ionic strength I = 0.1 M NaNO3. The metal–ligand formation constant of MA, MB, MAB and M1M2AB type of complexes follows Irving William order. The distribution curves of various complex species occurring at the different physiological pH have been discussed, and solution structures with an explanation of plausible equilibria have been proposed.

Keywords

Citrulline Tryptophan Thymine SCOGS computer program 

Notes

Acknowledgements

Authors are grateful to the UGC Rajiv Gandhi National Fellowship (JRF and SRF), New Delhi, for providing the financial assistance in completion of this research work.

References

  1. 1.
    Baldas J, Boas JF, Bonnyman J, Williams GA (1984) The preparation, characterisation, and electron spin resonance spectra of salts of tetrachloro- and Tetrabromo-nitridotechnetate(v1): crystal Structure of Tet rap heny la rson i u m Tet rac h I oron it r idotec h netate(vi). J Chem Soc Dalton Trans 1(2):1–3.  https://doi.org/10.1039/DT9840002395 CrossRefGoogle Scholar
  2. 2.
    Baldas J, Bonnyman J, Williams GA (1985) Structural studies of technetium complexes. VIII. The crystal structure of tetraphenylarsonium tetrabromonitridotechnetate(VI). Aust J Chem 38(1):215–219CrossRefGoogle Scholar
  3. 3.
    Burger K (1990) Biocoordination chemistry: coordination equilibria in biologically-active systems, Ellis Harwood, Chichester Springer 868 (2006). J Solut Chem 35:853–868Google Scholar
  4. 4.
    Kolthoy IM, Sandell BB, Meehan EJ, Bruckenstein A (1967) Quantitative chemical analysis. McMillan, LondonGoogle Scholar
  5. 5.
    Schwarzenbach G, Biedermann W (1948) Komplexone VII. Titration von Metallen mit Nitrilotriessigsäure H3X. Endpunktsindikation durch pH‐Effekte. Helv Chim Acta 31:331CrossRefGoogle Scholar
  6. 6.
    Shankar V, Mishra GK, Krishna V (2006) Multinuclear complexation equilibria of manganese(II), copper(II), zinc(II) and cadmium(II) with l-2-amino-3-methylbutanoic acid (valine) and nitrilotriacetic acid. J Indian Chem Soc 83(4):373–375Google Scholar
  7. 7.
    Bartaria D, Singh VP, Krishna V (2009) Chemical speciation and thermodynamic stability of quaternary mixed chelates of bio-metals involving lysine, proline and uracil. J Indian Chem Soc 86:9–13Google Scholar
  8. 8.
    Sayce IG (1968) Computer calculation of equilibrium constants of species present in mixture of metal ions and complexing agent. Talanta 15:1397CrossRefGoogle Scholar
  9. 9.
    Curis E, Nicolis I, Moinard C, Osowska S, Zerrouk N, Bénazeth S, Cynober L (2005) Almost all about citrulline in mammals. Amino Acids 29:177CrossRefGoogle Scholar
  10. 10.
    Barán EJ, Wagner CC, Torre MH, Kremer E, Kögerler P (2000) Espectros vibracionales de los complejos de Cu(II) con los ácidos aspártico y glutámico. Acta Farmacéutica Bonaerense 19(3):231–234Google Scholar
  11. 11.
    You YH, Zhang CP (2008) The photochemistry properties on interaction silver with tryptophan. Spectrochim Acta 69A:939–945ADSCrossRefGoogle Scholar
  12. 12.
    Nozati Y, Tanford C (1971) The Solubility of amino acids and two glycine peptides in aqueous ethanol and dioxane solutions: establishment of a hydrophobicity scale. J Biol Chem 246:2211Google Scholar
  13. 13.
    Ishida TB, Tokura Y, Shimamoto M, Doi M, Tnow M (1987) Crystal structure of (Uracil-1-ylethyl) (adenin-9-ylethyl) tryptophan dipeptide: an interaction model between nucleic acid base and aromatic. Amino Acid 35(5):1691–1701Google Scholar
  14. 14.
    Pullman and Pullman (1958) Electron-donor and -acceptor properties of biologically important purines, pyrimidines, pteridines, flavins, and aromatic amino acids. A Proc Natl Acad Sci USA 44:1197–1202ADSCrossRefGoogle Scholar
  15. 15.
    Hélène Claude, Lancelot Gérald (1982) Interactions between functional groups in protein-nucleic acid associations. Prog Biophys Mol Biol 39:1–68CrossRefGoogle Scholar
  16. 16.
    Abdel-Rahman LH, Battaglia LP, Mahmoud MR (1996) Synthesis, characterization and stability constant determination of l-phenylalanine ternary complexes of cobalt(II), nickel(II), copper(II) with N-heterocyclic aromatic bases and X-ray crystal structure of aqua-1,10-phenanthroline-l-phenylalaninatocopper(II) perchlorate complex. Polyhedron 15(2):327–334CrossRefGoogle Scholar
  17. 17.
    Mohamed GG, OmarAhmed MM, Hindy MM (2005) Synthesis, characterization and biological activity of some transition metals with Schiff base derived from 2-thiophene carboxaldehyde and aminobenzoic acid. Spectrochim Acta Part A Mol Biomol Spectrosc 62(4–5):1140–1150ADSCrossRefGoogle Scholar
  18. 18.
    Janssen MJ (1956) The stability constants of metal complexes of some N‐dialkyldithtocarbamic acids: Part. I. Copper complexes in 75% (v/v) ethanol water. Recueil des Travaux Chimiques des Pays-Bas 75(12):1411–1422CrossRefGoogle Scholar
  19. 19.
    Janssen MJ (1957) The stability constants of metal complexes of some N-dialkyldithiocarbamic acids: part II. Copper complexes in ethanol/water mixtures of various compositions. Recueil des Travaux Chimiques des Pays-Bas 76(10):827–835CrossRefGoogle Scholar
  20. 20.
    Taqui Khan MM, Satyanarayan S, Jyoti MS, Lincon A (1983) Thermodynamic quantities associated with interaction of thymine, uracil, cytosine, adenine and hypoxanthine with metal ions. Indian J Chem 22A:357Google Scholar
  21. 21.
    Taqui Khan MM, Krishnamourthy M (1973) Interaction of metal ions with disubstituted purines. J Inorg Nucl Chem 35:128Google Scholar
  22. 22.
    Taqui Khan MM, Satyanarayan S (1981) Metal complexes of uracil and mixed ligand metal complexes of uracil as a primary ligand and adenine, 1, 10-phenanthroline and 2, 2′-bipyridyl as secondary ligands. Indian J Chem 201A:817Google Scholar

Copyright information

© The National Academy of Sciences, India 2019

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of AllahabadAllahabadIndia
  2. 2.Department of Applied Sciences (Chemistry)United College of Engineering & ResearchAllahabadIndia

Personalised recommendations