Practical approaches on the long-acting injections

  • Yu-Chul Kim
  • Kyoung Ah Min
  • Dong-Jin Jang
  • Tae Young Ahn
  • Jae Hyeok Min
  • Byeong Eun Yu
  • Kwan Hyung ChoEmail author



Over the last several decades, long-acting injections have been studied in order to overcome such problems as low bioavailability in the oral route, the short durations of action in conventional injection, and the poor medication adherence in patients.

Area covered

The authors classified long-acting injections into three categories, namely, molecular modification, nanovehicle carriers, and stimuli-responsive hydrogels. The mechanisms and practical cases of these long acting injectable formulations, including conventional and recent technologies, were described and discussed in this review.

Expert opinion

Long-acting injection formulations has been proven to be useful from a number of preclinical and clinical studies. Therefore, the long-acting injection technologies can be promising strategy for precision and personalized medicine if the characteristics of formulation such as extended release and the drug-targeting are used appropriately.


Long-acting injection Molecular modification Nanovehicle Hydrogel 



This work was supported by the 2018 Inje University research grant.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involved in human and animal rights

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© The Korean Society of Pharmaceutical Sciences and Technology 2019

Authors and Affiliations

  • Yu-Chul Kim
    • 2
  • Kyoung Ah Min
    • 1
  • Dong-Jin Jang
    • 2
  • Tae Young Ahn
    • 1
  • Jae Hyeok Min
    • 1
  • Byeong Eun Yu
    • 1
  • Kwan Hyung Cho
    • 1
    Email author
  1. 1.College of Pharmacy and Inje Institute of Pharmaceutical Sciences and ResearchInje UniversityGimhaeRepublic of Korea
  2. 2.Department of Pharmaceutical EngineeringInje UniversityGimhaeRepublic of Korea

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