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Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)/poly(lactic-co-glycolic acid) micro and nanoparticles

  • Enas M. ElmowafyEmail author
  • Mattia Tiboni
  • Mahmoud E. Soliman
Review

Abstract

Background

Poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) are among the well-documented FDA-approved polymers used for the preparation of safe and effective vaccine, drug and gene delivery systems using well-described reproducible methods of fabrication. Various nano and microparticulates are fabricated using these polymers. Their successful performance relies on PLA and PLGA biocompatibility and degradability characteristics.

Area covered

This review provides an overview of the biocompatibility and biodegradation of PLA, PLGA and their copolymers, with a special emphasis on tissue responses for these polymers as well as their degradation pathways and drug release models. Moreover, the potential of PLA and PLGA based nano and microparticulates in various advanced biomedical applications is highlighted.

Expert opinion

PLA and PLGA based delivery systems show promises of releasing different drugs, proteins and nucleic acids in a stable and controlled manner and greatly ameliorating their therapeutic efficacy. In addition, advancement in surface modification and targeting of nanoparticles has extended the scope of their utility.

Keywords

Biocompatibility Biodegradation PLA PLGA Microparticles Nanoparticles 

Notes

Acknowledgements

This work was supported by Department of Pharmacy and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo-Egypt.

Compliance with ethical standards

Conflict of interest

The authors report no conflicts of interest in this work.

Statement of human and animal rights

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© The Korean Society of Pharmaceutical Sciences and Technology 2019

Authors and Affiliations

  • Enas M. Elmowafy
    • 1
    Email author
  • Mattia Tiboni
    • 2
  • Mahmoud E. Soliman
    • 1
  1. 1.Department of Pharmaceutics and Industrial Pharmacy, Faculty of PharmacyAin Shams UniversityCairoEgypt
  2. 2.Department of Biomolecular Sciences, School of PharmacyUniversity of UrbinoUrbinoItaly

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