Journal of Pharmaceutical Investigation

, Volume 49, Issue 1, pp 127–134 | Cite as

Modified sprouted rice for modulation of curcumin crystallinity and dissolution enhancement by solid dispersion

  • Thinh D. Luu
  • Beom-Jin Lee
  • Phuong H. L. Tran
  • Thao T. D. TranEmail author
Original Article


Sprouted grains, which is a natural polysaccharide, is the subject of increasing scientific interest due to many benefits for human health. The aim of the present work was to develop sprouted rice (SR) as a safe and useful material for application in dissolution enhancement of anticancer poorly water-soluble drugs such as curcumin by solid dispersions (SDs). SDs were prepared with pure SR and modified sprouted rice (MSR) by the melting method. The dissolution rate, drug crystallinity changes, molecular interactions and wettability were characterized and compared between the formulations. The use of MSR could result in a promising system for improving the dissolution rate of poorly water-soluble drugs. MSR could induce a greater amorphous state and improved wettability of drugs for dissolution enhancement compared to SR. Although both SR and MSR showed hydrogen bonding interaction, insignificant differences between SR and MSR were observed. We found that the crystallinity, interactions and wettability of the drug were significantly affected and modulated by MSR.


Solid dispersion Sprouted rice Modified sprouted rice Molecular interaction Crystallinity changes 



We would like to thank International University for the support to our studies.

Compliance with ethical standards

Conflict of interest

The authors confirm that this article content has no conflicts of interest.

Statement of human and animal rights

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© The Korean Society of Pharmaceutical Sciences and Technology 2018

Authors and Affiliations

  • Thinh D. Luu
    • 3
  • Beom-Jin Lee
    • 4
  • Phuong H. L. Tran
    • 5
  • Thao T. D. Tran
    • 1
    • 2
    Email author
  1. 1.Department for Management of Science and Technology DevelopmentTon Duc Thang UniversityHo Chi Minh CityVietnam
  2. 2.Faculty of PharmacyTon Duc Thang UniversityHo Chi Minh CityVietnam
  3. 3.International University, Vietnam National UniversityHo Chi Minh CityVietnam
  4. 4.Bioavailability Control Laboratory, College of PharmacyAjou UniversitySuwonRepublic of Korea
  5. 5.School of MedicineDeakin UniversityGeelongAustralia

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