Potential of nanoparticulate carriers for improved drug delivery via skin
- 81 Downloads
Skin as a delivery route for drugs has attracted a great attention in recent decades as it avoids many of the limitations of oral and parenteral administration. However, the excellent barrier property of skin is a major obstacle in the effective transport of drugs through this route. The topmost layer of skin, the “stratum corneum” is the tightest one and is responsible for most of the resistance offered. This necessitates breaching the resistance of the stratum corneum reversibly and transiently in order to achieve a therapeutically meaningful level in systemic circulation or local skin. In last few decades, a number of approaches have been developed to improve the limited drug permeability through stratum corneum. One promising approach is the use of nanoparticulate carriers as they not only facilitate drug delivery across skin but also avoid the drawbacks of conventional skin formulations. This review focuses on nanoparticulate carriers including conventional liposomes, deformable liposomes, ethosomes, niosomes and lipid nanoparticles developed for topical and transdermal drug delivery. A special emphasis is placed on their composition, structure, mechanism of penetration and recent application. The presented data demonstrate the potential of these nanoparticulate carriers for dermal and transdermal delivery.
KeywordsNanoparticulate carriers Skin permeation Liposomes Deformable liposomes Ethosomes Niosomes Lipid nanoparticles
This work was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1A2B4006458).
Compliance with ethical standards
Statement of human and animal rights
This article does not contain any studies with human or animal subjects performed by any of the authors.
Conflict of interest
The authors report no conflicts of interest in this work.
- Barry BW (1983) Dermatological formulations: percutaneous absorption. Marcel Dekker, New YorkGoogle Scholar
- Contri RV, Fiel LA, Pohlmann AR, Guterres SS, Beck RCR (2011) Transport of substances and nanoparticles across the skin and in vitro models to evaluate skin permeation and/or penetration. In: Beck R, Guterres S, Pohlmann A (eds) Nanocosmetics and nanomedicines. Springer, Berlin, pp 3–35CrossRefGoogle Scholar
- Kenneth AW, Michael SR (2002) The structure and function of skin. In: Kenneth AW (Ed.) Dermatological and transdermal formulations. CRC Press, Boca Raton, pp 1–39Google Scholar
- Muller RH, Mehnert W, Lucks JS, Schwarz C, Zur Muhlen A, Weyhers H, Freitas C, Ruhl D (1995) Solid lipid nanoparticles (SLN)—an alternative colloidal carrier system for controlled drug delivery. Eur J Pharm Biopharm 41:62–69Google Scholar
- Muzzalupo R, Tavano L (2015) Niosomal drug delivery for transdermal targeting: recent advances. Res Rep Transderm Drug Deliv 4:23–33Google Scholar
- Perez AP, Altube MJ, Schilrreff P, Apezteguia G, Celes FS, Zacchino S, de Oliveira CI, Romero EL, Morilla MJ (2016) Topical amphotericin B in ultradeformable liposomes: formulation, skin penetration study, antifungal and antileishmanial activity in vitro. Colloids Surf B Biointerfaces 139:190–198CrossRefPubMedGoogle Scholar
- Ranade VV, Cannon JB (2011) Drug delivery systems, 3 rd edn. CRC Press, Boca RatonGoogle Scholar
- Rosen MR (2005) Delivery system handbook for personal care and cosmetic products: technology, applications and formulation, 1st ed. William Andrew, NorwichGoogle Scholar
- Solanki AB, Parikh JR, Parikh RH, Patel MR (2010) Evaluation of different compositions of niosomes to optimize aceclofenac transdermal delivery. Asian J Pharm Sci 5:87–95Google Scholar
- Subongkot T, Ngawhirunpat T (2015) Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes. Int J Nanomed 10:4581–4592Google Scholar
- Touitou E (1996) Compositions for applying active substances to or through the skin. US patent 5,540,934Google Scholar
- Uchechi O, Ogbonna JD, Attama AA (2014) Nanoparticles for dermal and transdermal drug delivery. In: Sezer AD (Ed.) Nanotechnology and nanomaterials: application of nanotechnology in drug delivery. InTech, Rijeka, pp 193–235Google Scholar
- Uner M, Yener G (2007) Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. Int J Nanomed 2:289–300Google Scholar