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Journal of Pharmaceutical Investigation

, Volume 48, Issue 2, pp 153–165 | Cite as

Recent alternative approaches of vascular drug-eluting stents

  • Cheol-Min Han
  • Kwang-Sook Park
  • Yoon Ki JoungEmail author
Review

Abstract

Vascular stent is tubular shaped medical device designed to treat occluded circulatory or digestive systems by opening the blocked vascular sites. Originally stents were made of bare metals, such as stainless steel and cobalt–chromium alloys, due to their inherent corrosion resistance and good mechanical properties. Damage of intimal layer during expansion of stent, however, have caused neointimal hyperplasia resulting in in-stent restenosis which is one of main complications of vascular stent treatment. Drug-eluting stents (DESs) were introduced to alleviate this restenosis by local delivery of anti-proliferative drugs to the implanted or inserted site. The DES systems have been developed over the years by making changes in its main component, namely, drug, polymeric coating layer and expandable scaffold. Nevertheless, late thrombosis caused by drugs themselves and polymeric coating layer still remains as a serious problem of DES systems. Numerous studies, therefore, consistently focus on more advanced DES systems to solve the current issues. In this mini review article, we cast an opinion on how to improve the potential of DES system by means of (i) summarizing the history of DES system developed so far and (ii) updating current advances for the future generation of DES system.

Keywords

Vascular stent Drug eluting stent Restenosis Thrombosis Anti-inflammation Re-endothelialization 

Notes

Acknowledgements

This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by Ministry of Science and ICT (NRF-2014M3A9D3033887 and NRF-2015M3A9E2028580), and Strategic Core Materials Technology Development Program (10062079) funded by Ministry of Trade Industry and Energy (MOTIE), Republic of Korea.

Disclosure

Cheol-Min Han, Kwang-Sook Park and Yoon Ki Joung declare that they have no conflict of interest.

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Copyright information

© The Korean Society of Pharmaceutical Sciences and Technology 2017

Authors and Affiliations

  • Cheol-Min Han
    • 1
  • Kwang-Sook Park
    • 1
  • Yoon Ki Joung
    • 1
    • 2
    Email author
  1. 1.Center for BiomaterialsKorea Institute of Science and TechnologySeoulSouth Korea
  2. 2.Division of Bio-Medical Science and TechnologyUniversity of Science and Technology (UST)DaejeonSouth Korea

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