Enhanced photodyamic therapy via photosensitizer-loaded nanoparticles for cancer treatment
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Cancer is one of the most challenging human disease to cure, and has high rate to death. The current major cancer treatments include surgery, chemotherapy and radiation therapy. However, these treatments have a lot of obstacles that included low efficacy, mortality and severe aftereffects. Photodynamic therapy is developing cancer therapy that photosensitizer (PS) transfers energy from light to molecular oxygen damaged to generate reactive oxygen species (ROS). These reactions occur in the immediate locale of the light-absorbing PS. Almost of PSs have obstacle to adjust in human body system. Nanoparticle systems (NS) were used to overcome problems like drug solubility, delivery and low efficacy. Nanoparticles loaded anticancer drug, small molecule drug, biomedicine and PSs. In this review, we summarize the studies that have confirmed the nanoparticle systems loading PSs which are Phthalocyanine 4, Photofrin®, Temoporfin, Levulan® and Foscan® cancer therapy and discuss the future direction for the this novel therapy.
KeywordsNanoparticles Photodynamic therapy Photosensitizer Drug delivery Tumor
This research was supported by the Basic Science Research Program (NRF-2017R1A2B4002743) and the Pioneer Research Center Program (NRF 2014M3C1A3054153) of the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology.
Compliance with ethical standards
Conflict of interest
All authors (G. Jeon, Y. T. KO) declare that they have no conflict of interest.
Statement of human and animal rights
This article does not contain any studies with human and animal subjects performed by any of the authors.
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