Mesoporous silica-based nanoplatforms for the delivery of photodynamic therapy agents
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Photodynamic therapy (PDT) is an established method for the treatment of cancer which utilizes light, a photosensitizer (PS), and oxygen. Unfavourable characteristics of most PSs, such as low solubility and tumour specificity have led many researchers to adopt nanoscale drug delivery platforms for use in PDT. Mesoporous silica nanoparticles (MSNs) form a significant part of that effort, due to their ease and controllability of synthesis, ease of loading, availability of diverse surface functionalization, and biocompatibility. Therefore, in this review, we discuss the properties of MSNs as they pertain to their use in PDT and review the latest advances in the field, comparing the different approaches currently being used.
KeywordsPhotodynamic therapy Mesoporous silica Drug delivery Nanocarrier Biocompatibility Theranostic platform Controlled release
This work was supported by the National Research Foundation of Korea (NRF) (Grant Nos. NRF-2015M2A2A6A01044298 and 2014R1A2A1A11050923).
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Conflict of interest
All authors declare that they have no conflict of interest.
Statement of human and animal rights
This article does not contain any studies with human or animal subjects performed by any of the authors.
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