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Infection

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Antagonistic effect between tigecycline and meropenem: from bed to bench to bed

  • Lavinia Arend
  • João Paulo Telles
  • Felipe Francisco TuonEmail author
Correspondence
  • 53 Downloads

Notes

Compliance with ethical standards

Conflict of interest

Felipe Tuon has received research grants from Pfizer and MSD in the last year. Felipe Tuon conducts research for CNPQ.

References

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    Bi S, Yao X, Huang C, et al. Antagonistic effect between tigecycline and meropenem: successful management of KPC-producing Klebsiella pneumoniae infection. Infection. 2019;47:497–500.CrossRefGoogle Scholar
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    Tuon FF, Graf ME, Merlini A, et al. Risk factors for mortality in patients with ventilator-associated pneumonia caused by carbapenem-resistant Enterobacteriaceae. Braz J Infect Dis. 2017;21:1–6CrossRefGoogle Scholar
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    Toledo PV, Aranha Junior AA, Arend LN, Ribeiro V, Zavascki AP, Tuon FF. Activity of antimicrobial combinations against KPC-2-producing Klebsiella pneumoniae in a rat model and time-kill assay. Antimicrob Agents Chemother. 2015;59:4301–4.CrossRefGoogle Scholar
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    Toledo PV, Tuon FF, Arend L, Aranha Junior AA. Efficacy of tigecycline, polymyxin, gentamicin, meropenem and associations in experimental Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae non-lethal sepsis. Braz J Infect Dis. 2014;18:574–5.CrossRefGoogle Scholar
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    Stein C, Makarewicz O, Bohnert JA, et al. Three dimensional checkerboard synergy analysis of colistin, meropenem, tigecycline against multidrug-resistant clinical Klebsiella pneumonia isolates. PLoS One. 2015;10:e0126479.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Laboratory of Emerging Infectious Diseases, School of MedicinePontifícia Universidade Católica do ParanáCuritibaBrazil
  2. 2.Laboratório Central do Estado (LACEN-PR)CuritibaBrazil
  3. 3.Infectious Diseases DepartmentAC Camargo Cancer CenterSão PauloBrazil

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