Post-malaria neurological syndrome: a rare neurological complication of malaria
- 291 Downloads
Post-malaria neurological syndrome (PMNS) is a rare self-limiting neurological complication that can occur after recovery from malaria, usually severe falciparum malaria. It is characterized by a myriad of neuropsychiatric manifestations including mild neurological deficit to severe encephalopathy. PMNS was first described in 1996 and since then there have been 48 cases reported in the English literature. We report another case of PMNS in a 24-year-old healthy male and present a review of the disease entity.
We searched PMNS-related journal articles and case reports in the English literature, using PubMed and Google search engines. A total of forty-nine cases meeting the diagnostic criteria of PMNS were selected in this review.
PMNS is a rare complication of severe malaria that might be underreported. It can develop up to 2 months after clearance of parasitemia. Clinical features can be variable. Most cases are self-limited, but more severe cases may benefit from steroid therapy.
KeywordsPost-malaria neurological syndrome (PMNS) Falciparum malaria
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
- 10.Silva-Pinto A, Costa A, Alves J, Silva NN, Abreu C, Santos L, Sarmento A. Post-malaria neurological syndrome: report of 3 cases from a Portuguese malaria reference centre. 2017. https://www.escmid.org/escmid_publications/escmid_elibrary. Accessed 24 Apr 2017
- 19.Mittal S, Misri ZK, Rakshith KC, Mittal S. Post malarial neurological syndrome: an uncommon cause. J Neuroinfect Dis. 2015;S1:004.Google Scholar
- 25.Donati D, Zhang LP, Chêne A, Chen Q, Flick K, Nyström M, Wahlgren M, Bejarano MT. Identification of a polyclonal B-cell activator in Plasmodium falciparum. Infect Immun. 2004;72:5412–8. Erratum in: Infect Immun. 2005;73:7790.Google Scholar