, Volume 47, Issue 2, pp 331–332 | Cite as

Daptomycin-associated myopathy induced by concomitant administration of mirabegron

  • Hideharu HagiyaEmail author
  • Ryohei Kokado
  • Hideo Okuno
  • Kazunori Tomono

To the Editor,

Daptomycin (DAP) belongs to a new class of antibiotics and possesses bactericidal activity against Gram-positive organisms [1]. Currently, this agent is recommended for the treatment of methicillin-resistant Staphylococcus aureus infections and frequently used in various clinical settings [2]. Muscle toxicity is one of the common adverse drug events associated with DAP administration. Incidence rates of myopathy and rhabdomyolysis among patients receiving DAP are estimated about 2–14% and < 5%, respectively [3]. Coadministration of statin [3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors] and antihistamine with DAP is an independent risk factor for the development of DAP-associated myopathy [3]. However, effects of other drugs are still unknown. We describe a first case of DAP-associated myopathy, which was induced by the concomitant administration of mirabegron.

A 57-year-old woman (body weight, 70.8 kg) developed a high fever without remarkable...



None to report.

Compliance with ethical standards

Conflict of interest

The authors confirm that there are no conflicts of interests to declare.

Informed consent

Informed consent was obtained from the patient.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Infection Control and PreventionOsaka University HospitalSuitaJapan
  2. 2.Department of PharmacyOsaka University HospitalOsakaJapan

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