, Volume 47, Issue 2, pp 285–288 | Cite as

Chronic meningococcemia: a report of 26 cases and literature review

  • Benjamin Lefèvre
  • Yves Poinsignon
  • Caroline Piau
  • François-Charles Javaugue
  • Jean-Philippe Talarmin
  • Maeva Lefebvre
  • Nicolas Varache
  • Hélène Drouin
  • Pierre TattevinEmail author
  • pour le Groupe d’Epidémiologie et Recherche en Infectiologie Clinique du Centre et de l’Ouest (GERICCO)
Brief Report


Chronic meningococcemia is defined by blood culture(s) positive for Neisseria meningitidis, symptoms duration > 7 days, and neither meningitis nor shock on admission. This series of 26 consecutive cases illustrates that this is a rare disease (< 5% of meningococcemia, < 0.05 cases per 100,000 inhabitants per year), mostly affecting young adults, males, with no predisposing condition. Major symptoms include fever, rash, and arthralgia. Median time between symptoms onset, and diagnosis is 28 days. Most patients fully recover with a 1-week course of parenteral betalactams.


Neisseria meningitidis Meningococcemia Chronic Virulence Immunity 



No funding was received for this study.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

This study has been approved by the CER-MIT Ethics committee.

Supplementary material

15010_2018_1238_MOESM1_ESM.docx (32 kb)
Supplementary material 1 (DOCX 32 KB)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Benjamin Lefèvre
    • 1
  • Yves Poinsignon
    • 2
  • Caroline Piau
    • 3
  • François-Charles Javaugue
    • 4
  • Jean-Philippe Talarmin
    • 5
  • Maeva Lefebvre
    • 6
  • Nicolas Varache
    • 7
  • Hélène Drouin
    • 8
  • Pierre Tattevin
    • 1
    Email author
  • pour le Groupe d’Epidémiologie et Recherche en Infectiologie Clinique du Centre et de l’Ouest (GERICCO)
  1. 1.Infectious Diseases and Intensive Care UnitPontchaillou University HospitalRennes Cedex 9France
  2. 2.Infectious Diseases and Internal MedicineBretagne-Atlantique HospitalVannesFrance
  3. 3.MicrobiologyPontchaillou University HospitalRennesFrance
  4. 4.PharmacyLa Milêtrie University HospitalPoitiersFrance
  5. 5.Infectious Diseases and Internal MedicineCornouailles HospitalQuimperFrance
  6. 6.Infectious Diseases and Tropical MedicineHôtel Dieu University HospitalNantesFrance
  7. 7.Infectious Diseases and Internal MedicineGeneral HospitalLe MansFrance
  8. 8.Infectious Diseases and Internal MedicineGeneral HospitalLavalFrance

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