, Volume 46, Issue 6, pp 861–865 | Cite as

Diagnosis of nontuberculous mycobacterial disease in the era of surveillance chest CT scans

  • Andrew Calzadilla
  • Greg Holt
  • Michael Campos
  • Mehdi MirsaeidiEmail author
Brief Report


The radiologic surveillance of smokers with low-dose CT scan has led to a significant surge of radiologic incidental findings, including the detection of early stages of pulmonary infections including nontuberculous mycobacteria (NTM). This causes a state of overdiagnosis and potential overtreatment of NTM lung disease. Here we propose a new approach to NTM pulmonary disease in the era of increased CT scanning.


Nontuberculous MAC Mycobacterial Lung disease 



This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

All authors report no conflict of interest. Guarantor of the paper: Mehdi Mirsaeidi MD, MPH.


  1. 1.
    Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175:367–416. Scholar
  2. 2.
    National Lung Screening Trial, Research T, Church TR, Black WC, Aberle DR, Berg CD, Clingan KL, et al. Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med. 2013;368:1980–91. Scholar
  3. 3.
    Moyer VA, Force USPST. Screening for lung cancer: US Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;160:330–8. Scholar
  4. 4.
    Winthrop KL, McNelley E, Kendall B, Marshall-Olson A, Morris C, Cassidy M, et al. Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health disease. Am J Respir Crit Care Med. 2010;182:977–82. Scholar
  5. 5.
    Johnson MM, Odell JA. Nontuberculous mycobacterial pulmonary infections. J Thorac Dis. 2014;6:210–20. Scholar
  6. 6.
    Mirsaeidi M, Farshidpour M, Ebrahimi G, Aliberti S, Falkinham JO III. Management of nontuberculous mycobacterial infection in the elderly. Eur J Intern Med. 2014;25:356–63. Scholar
  7. 7.
    Marras TK, Campitelli MA, Kwong JC, Lu H, Brode SK, Marchand-Austin A, et al. Risk of nontuberculous mycobacterial pulmonary disease with obstructive lung disease. Eur Respir J. 2016;48:928–31. Scholar
  8. 8.
    Viviani L, Harrison MJ, Zolin A, Haworth CS, Floto RA. Epidemiology of nontuberculous mycobacteria (NTM) amongst individuals with cystic fibrosis (CF). J Cyst Fibros. 2016;15:619–23. Scholar
  9. 9.
    Kuru T, Lynch JP III. Nonresolving or slowly resolving pneumonia. Clin Chest Med. 1999;20:623–51.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Pulmonary, Allergy, Critical Care and Sleep MedicineUniversity of MiamiMiamiUSA
  2. 2.Section of Pulmonary, Department of MedicineMiami VA Health SystemMiamiUSA
  3. 3.Division of Pulmonary and Critical Care, Miller School of MedicineUniversity of MiamiMiamiUSA

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