Health-related quality of life in patients with alveolar echinococcosis: a cross-sectional study
- 56 Downloads
The Alveolar echinococcosis (AE) is a rare zoonosis caused by the parasite Echinococcus multilocularis. To date, nothing is known about the health-related quality of life (HRQoL) in patients with AE. The aim of the study was to evaluate the HRQoL in patients with AE in comparison of the healthy population.
We used the 36-Item Short Form Health Survey (SF-36) questionnaire to evaluate the HRQoL. The SF-36 scales have a range of 0–100 (0 represents the worst and 100 the most favourable state of health). SAS Version 9.2 was used for the statistical analysis of AE-cases (n = 30) and the healthy control group (n = 35).
The analysis showed that the HRQoL in people with AE is reduced in comparison with the control population. The study group consisted of 15 (50.0%) men and 15 (50.0%) women; the control group of 16 (45.7%) men and 19 (54.3%) women. The mean age was 55.73 ± 16.65 years, while that of the control group was 54.57 ± 15.34 years. The physical quality of life in patients with AE (45.21 ± 11.42) was not significantly less than that of the control group (50.54 ± 10.52); p = 0.0568. Nevertheless, AE-patients show lower SF-36 scores for the physical quality of life. For the mental quality of life, patients with AE had a significantly lower score (45.46 ± 10.57) than the control group (51.57 ± 9.04); p = 0.0154.
The HRQoL in people with AE is reduced in comparison with a control population. Assessment of the physical and mental quality of life in patients with AE may help to evaluate the patient outcome.
KeywordsAlveolar echinococcosis Echinococcus multilocularis Health-related quality of life Healthy control group SF-36 questionnaire
Members of the echinococcosis working group: Thomas FE Barth, Sven Baumann, Doris Henne-Bruns, Tilmann Gräter, Andreas Hillenbrand, Tanja Kaltenbach, Frauke Theis.
The results are from a German Research Foundation (DFG) funded project called “Establishment of a national database for alveolar echinococcosis” (Ref. No. KA 4356/3-1).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
The study was approved by the local Ethics Committee approval and the Declaration of Helsinki (ref. No. 63/18).
- 15.Kern P, Ammon A, Kron M, Sinn G, Sander S, Petersen LR, Gaus W, Kern P. Risk factors for alveolar echinococcosis in humans. Emerg Infect Dis. 2004;10:2088–93.Google Scholar
- 25.Torgerson PR, Schweiger A, Deplazes P, Pohar M, Reichen J, Ammann RW, Tarr PE, Halkik N, Müllhaupt B. Alveolar echinococcosis: from a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years. J Hepatol. 2008;49:72–7.CrossRefGoogle Scholar
- 28.Bullinger M. Das Konzept der Lebensqualität in der Medizin: Entwicklung und heutiger Stellenwert. Lebensqualität im Gesundheitswesen: Wissen wir, was wir tun? (2013).Google Scholar
- 29.Bullinger M, Kirchberger I. SF-36 Fragebogen zum Gesundheitszustand. Handanweisung: Hogrefe Verlag für Psychologie Göttingen; 1998.Google Scholar
- 31.Weltgesundheitsorganisation. Bangkok Charta für Gesundheitsförderung in einer globalisierten Welt. 2005. http://www.who.int/healthpromotion/conferences/6gchp/BCHP_German_version.pdf. Accessed 17 Sept 2018.
- 36.Kalter J, Verdonck-de Leeuw IM, Sweegers MG, Aaronson NK, Jacobsen PB, Newton RU, Courneya KS, Aitken JF, Armes J, Arving C, Boersma LJ, Braamse AM, Brandberg Y, Chambers SK, Dekker J, Ell K, Ferguson RJ, Gielissen MF, Glimelius B, Goedendorp MM, Graves KD, Heiney SP, Horne R, Hunter MS, Johansson B, Kimman ML, Knoop H, Meneses K, Northouse LL, Oldenburg HS, Prins JB, Savard J, van Beurden M, van den Berg SW, Brug J, Buffart LM. Effects and moderators of psychosocial interventions on quality of life, and emotional and social function in patients with cancer: an individual patient data meta-analysis of 22 RCTs. Psychooncology. 2018;27:1150–61.CrossRefGoogle Scholar