, Volume 47, Issue 1, pp 115–119 | Cite as

Overdose of elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide in an HIV-1-infected subject with attempted suicide

  • Hortensia ÁlvarezEmail author
  • Ana Mariño
  • Nieves Valcarce
  • Jesús García-González
  • Helena Díaz-Cambre
  • Josep M. Llibre
Case Report



Data are lacking regarding overdose of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF).

Material and methods

We present the first report of suicidal attempt with E/C/F/TAF in a Human Immunodeficiency Virus-infected subject.


A reversible acute renal failure with no proximal tubulopathy and neuropsychiatric issues are discussed. E/C/F/TAF withdrawal resulted in favourable renal and neuropsychiatric outcomes. The suicide attempt seemed unrelated to the integrase strand transfer inhibitor, being evenly explained within the context of stressful personal conflicts.


A suicidal attempt with an E/C/F/TAF overdose in an HIV-infected patient, resulted in a favourable outcome from a renal and neuropsychiatric standpoint.


Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide Overdose Suicide attempt 


Compliance with ethical standards

Conflict of interest

Hortensia Álvarez has received support for attending meetings from Janssen-Cilag, Gilead Sciences, ViiV Healthcare, AbbVie, and Merck Sharp and Dohme. Ana Mariño has received support for attending meetings from Bristol-Myers Squibb, Gilead Sciences, Janssen-Cilag and ViiV Healthcare. Josep M. Llibre has received grants from ViiV Healthcare and has received honoraria and consulting fees from Gilead Sciences, Merck Sharp and Dohme, Bristol-Myers Squibb, and ViiV Healthcare, all them outside the submitted work. The remaining authors declare no relevant conflicts of interest to the content of the manuscript.

Human rights statement

This is a research involving a human participant. The patient provided written consent for publication of his clinical record.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Hortensia Álvarez
    • 1
    Email author
  • Ana Mariño
    • 1
  • Nieves Valcarce
    • 2
  • Jesús García-González
    • 3
  • Helena Díaz-Cambre
    • 4
  • Josep M. Llibre
    • 5
  1. 1.Infectious Diseases Unit, Internal Medicine DepartmentUniversity Hospital of FerrolFerrol, A CoruñaSpain
  2. 2.Hospital PharmacyUniversity Hospital of FerrolA CoruñaSpain
  3. 3.Psychiatry DepartmentUniversity Hospital of FerrolA CoruñaSpain
  4. 4.Nephrology DepartmentUniversity Hospital of FerrolA CoruñaSpain
  5. 5.Infectious Diseases and “Fight AIDS” FoundationUniversity Hospital Germans Trias i PujolBarcelonaSpain

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