, Volume 46, Issue 5, pp 705–710 | Cite as

Disseminated nocardiosis caused by Nocardia elegans: a case report and review of the literature

  • Yi YouEmail author
  • Wenchief Chen
  • Baiyu Zhong
  • Ziqiang Song
  • Xichuan Yang
Case Report



Disseminated nocardiosis is a rare disease mostly occurring in immunocompromised patients.


We report a case of disseminated nocardiosis in a diabetic patient with both pulmonary and cutaneous involvement. Nocardia elegans was isolated and identified using the 16s ribosomal RNA gene sequence data.


Clinical improvement was observed within 3 months after initiation of antimicrobial treatment with oral doxycycline, trimethoprim-sulfamethoxazole and intravenous penicillin, but the patient died 5 months later after arbitrary discontinuation of the treatment.


This is the first case report of disseminated nocardiosis caused by Nocardia elegans in China.


Nocardia elegans Nocardiosis 16s ribosomal RNA Gene sequencing 



We thank Danqi Deng (Dermatology Department of the Second Affilliated Hospital of Kunming Medical College), Yun Guo (Dermatology Deparment of the Second Affiliated Hospital of Kunming Medical College), Yongxia Wang (Yunnan Institute of Microbiology, Yunnan University,) and Xiaolong Cui (Yunnan Institute of Microbiology, Yunnan University) for assistance in the identification of the Nocardia species.


This study was supported by the National Natural Science Foundation of China (no. 81673058) and the Clinical Research Funding of Southwest Hospital (SWH2016JSTSYB-29).

Compliance with ethical standards

Conflict of interest

None declared.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Yi You
    • 1
    Email author
  • Wenchief Chen
    • 2
  • Baiyu Zhong
    • 1
  • Ziqiang Song
    • 1
  • Xichuan Yang
    • 1
  1. 1.Department of Dermatology, Southwest HospitalThird Military Medical UniversityChongqingChina
  2. 2.Department of Dermatology and AllergyTechnische Universitaet MuenchenMunichGermany

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