Applied Biological Chemistry

, Volume 61, Issue 6, pp 697–701 | Cite as

Cell growth inhibitory effects of polyphenols with naphthalene skeleton against cisplatin-resistant ovarian cancer cells

  • Soon Young Shin
  • Youngshim Lee
  • Jihyun Park
  • Doseok Hwang
  • Geunhyeong Jo
  • Ji Hye Lee
  • Dongsoo Koh
  • Yoongho LimEmail author


Cisplatin often shows the drug resistance which could limit the chemotherapeutic efficacy. Thus, it is necessary to develop anticancer agents against cisplatin-resistant cancer cells. To identify pharmacophores exhibiting the cell growth inhibitory effect against cisplatin-resistant A2780/Cis ovarian cancer cells, we prepared 35 synthetic polyphenols bearing naphthalene skeleton including naphthalenyl chalcones, naphthalenyl flavones, naphthalenyl flavanones, 4,5-dihydro-1H-pyrazol-3-yl)naphthalen-2-ols, naphthalen-1-yl-N-phenyl-4,5-dihydro-1H-pyrazole-1-carbothioamides, and 4,5-dihydro-1H-pyrazol-3-yl)naphthalen-1-ol. The correlation between their inhibitory effects and structural properties was evaluated using hologram quantitative structure activity relationship and comparative molecular field analysis. The pharmacophores derived here can lead us to design new polyphenols against the growth of cisplatin-resistant cells.


Cisplatin-resistant ovarian cancer Clonogenicity Comparative molecular field analysis Hologram quantitative structure activity relationship Polyphenols 



This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (Grant No. NRF-2016R1D1A1A09919045), Republic of Korea. This paper was supported by the KU Research Professor Program of Konkuk University.

Supplementary material

13765_2018_403_MOESM1_ESM.doc (948 kb)
Supplementary material 1 (DOC 948 kb)


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Copyright information

© The Korean Society for Applied Biological Chemistry 2018

Authors and Affiliations

  • Soon Young Shin
    • 1
  • Youngshim Lee
    • 2
  • Jihyun Park
    • 2
  • Doseok Hwang
    • 2
  • Geunhyeong Jo
    • 2
  • Ji Hye Lee
    • 3
  • Dongsoo Koh
    • 3
  • Yoongho Lim
    • 2
    Email author
  1. 1.Department of Biological SciencesKonkuk UniversitySeoulRepublic of Korea
  2. 2.Division of Bioscience and Biotechnology, BMICKonkuk UniversitySeoulRepublic of Korea
  3. 3.Department of Applied ChemistryDongduk Women’s UniversitySeoulRepublic of Korea

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