Slow release formulation of herbicide metazachlor based on high molecular weight poly(lactic acid) submicro and microparticles

  • J. Salač
  • T. Šopík
  • P. Stloukal
  • N. Janásová
  • M. Jursík
  • M. KoutnýEmail author
Original Paper


Frequently used pre-emergent herbicide metazachlor was encapsulated into high molecular weight poly(lactic acid) particles, and its subsequent release and the effectivity of such formulations were investigated. Two sets of polymeric micro- and submicro particles, both with the theoretical metazachlor loading of 20%, 30%, and 40%, were prepared and characterized. Loading efficiency reached 80% for both types of particles. Release profiles were tested in vitro for the individual particle variants and were shown to have a bimodal profile with the initial fast burst release and much slower second phase. Finally, selected formulations were tested in vivo against target plants (field poppy and barnyard grass) and non-targets plants (mustard and rapeseed) and showed improved inhibition of target plants (about 30% higher for barnyard grass) and at the same time lower inhibition of non-target plants (rapeseed) in comparison with the identical dose of metazachlor alone.


Poly(lactic acid) Metazachlor Herbicide Controlled release Microparticles 



Financial support from Tomas Bata University in Zlín, Internal Grant Agencies (Project IGA/FT/2018/009 and IGA/FT/2019/011) was gratefully acknowledged.


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Copyright information

© Islamic Azad University (IAU) 2019

Authors and Affiliations

  1. 1.Department of Environmental Protection Engineering, Faculty of TechnologyTomas Bata UniversityZlínCzech Republic
  2. 2.Department of Food Technology, Faculty of TechnologyTomas Bata UniversityZlínCzech Republic
  3. 3.Department of Agroecology and Biometeorology, Faculty of Agrobiology, Food and Natural ResourcesCzech University of Life Sciences PraguePragueCzech Republic

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