Multiple cavernous malformations as a cause for superficial siderosis of the central nervous system
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A 56-year-old man with a past medical history of hypertension and Crohn’s disease was referred to our clinic for slowly progressive gait ataxia with episodes of vertigo and bilateral deafness with progressive worsening over the past 18 months.
He also complained of cognitive impairment for a few years. The patient did not present sudden headache nor stiff neck.
He had no history of neurosurgical procedures, brain tumors, nor cranial or spinal injuries. His familial history was unremarkable.
Clinical examination revealed severe gait impairment in relation with cerebella ataxia, bilateral sensorineural hearing loss and tetrapyramidal syndrome (hyperreflexia and extensor plantar responses).
KeywordsSuperficial siderosis of the central nervous system Cerebral hemorrhage Cavernoma Developmental venous anomaly Deafness
CR: study concept and design. LS: critical revision of the manuscript for important intellectual content. EG-M: critical revision of the manuscript for important intellectual content. J-PB: critical revision of the manuscript for important intellectual content. BH: study concept and design.
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Conflict of interest
Clément Richard declares that he has no conflict of interest. Laura Simmonet declares that she has no conflict of interest. Evelyne Guegan-Massardier declares that she has no conflict of interest. Jean-Paul Bouwyn declares that he has no conflict of interest. Benjamin Hebant declares that he has no conflict of interest. The authors report no financial disclosures relevant to the manuscript.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.