Tibial motor and sural electrophysiological relationship in subjects without and patients with mild axonal peripheral neuropathy
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The distal motor fibers of the tibial and sural nerves are predominantly derived from the S1 root. We aimed to describe the electrophysiological relationship of these two nerves. Clinical, radiological and neurophysiological data of patients with mild, length-dependent, peripheral neuropathy (PN) and subjects without PN were retrospectively collected and analyzed. Eighty-eight individuals without PN and 24 patients with mild axonal PN who had no evidence of lumbosacral radiculopathy were included for analysis. Significant positive correlations were observed for the tibial CMAP and the sural SNAP for both controls and patients. Multivariate linear regression analyses showed that the predicted tibial CMAP can be calculated using the following equations: for male subjects without PN, tibial CMAP = 20.7 − 0.21 × age; for female subjects without PN, tibial CMAP = 23.3 − 0.21 × age and for patients with mild PN, tibial CMAP = 2.7 + sural SNAP. This study demonstrates the high correlation between the tibial CMAP and the sural SNAP in subjects without PN and patients with mild axonal peripheral neuropathy, and provides mathematical equations for the calculation of the predicted tibial CMAP for such individuals.
KeywordsPolyneuropathy Tibial nerve Sural nerve Electrodiagnostic Radiculopathy Screening
Sensory nerve action potential
Compound muscle action potential
This is a summary of an independent research supported by BRC and carried out at the National Institute for Health Research (NIHR) Sheffield Clinical Research Facility. The views expressed are those of the authors and not necessarily those of the BRC, NHS, the NIHR or the Department of Health. Dr. Zis is sincerely thankful to the Ryder Briggs Fund. We are sincerely thankful to Dr. Dasappaiah Ganesh Rao for his contribution in the collection of the data.
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Conflict of interest
None of the authors have any conflict of interest to disclose.
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