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A rare case of spinal epidural sarcoidosis: case report and review of the literature

  • Francesco PagliaEmail author
  • Luca D’Angelo
  • Daniele Armocida
  • Luigi Sampirisi
  • Felice Giangaspero
  • Ludovica De Vincentiis
  • Antonio Santoro
Original article
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Abstract

Sarcoidosis is a rare systemic disease characterized by growth and organization of inflammatory cells in a granuloma. Granulomas can localize in any parts of the human body. The main localization is represented by lungs, lymph nodes, eyes and skin. Any organ, however, can be affected. Central nervous system (CNS) represents a rare localization of sarcoidosis, in fact, only 1% of patient with sarcoidosis present brain and/or spinal cord localization of the granulomas associated with this disease. This condition takes the name of Neurosarcoidosis. Its diagnosis and management pose a significant challenge, as its clinical manifestation and appearance in imaging studies are difficult to distinguish from more common lesion of the spinal cord. In this paper, we present the case of a 45-year-old woman who presented back pain associated with neurologic signs of myelopathy. Spinal cord MRI documented a T2 hyperintense signal around medullary conus. She underwent a gross total removal of the lesion. Histopathological examination revealed spinal sarcoidosis. Next total body CT scan did not show other localization of the disease. The aim of the present paper is to report a very rare case of spinal epidural sarcoidosis, actually only five cases have been described, without other localization of the disease. The present article underlines the difference between this forms of spinal sarcoidosis compared to intradural extramedullary and intramedullary spinal sarcoidosis.

Keywords

Sarcoidosis Neurosarcoidosis Epidural sarcoidosis Myelopathy 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain studies with animals by the author.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Belgian Neurological Society 2019

Authors and Affiliations

  • Francesco Paglia
    • 1
    Email author
  • Luca D’Angelo
    • 1
  • Daniele Armocida
    • 1
  • Luigi Sampirisi
    • 1
  • Felice Giangaspero
    • 2
    • 3
  • Ludovica De Vincentiis
    • 2
  • Antonio Santoro
    • 1
  1. 1.Department of Neurology and Psychiatry, Neurosurgery‘Sapienza’ University of RomeRomeItaly
  2. 2.Department of Radiological and Pathological Science‘Sapienza’ University of RomeRomeItaly
  3. 3.Neuromed Institute, IRCCSPozzilliItaly

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