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Association between serum apolipoprotein E and cognitive functions in Egyptian patients with temporal lobe epilepsy

  • Iman Elbanhawy
  • Ebtesam Mohamed Fahmy
  • Sahar Sharaf
  • Rania Shehata IsmailEmail author
  • Karim Elmehdawy
Original article

Abstract

Memory, cognition and visuospatial aspects of temporal lobe epilepsy (TLE) have not been fully analyzed yet. From among the huge growing population of circulating apoproteins analyzed in TLE, apolipoprotein E (APOE) was discovered; however, its role in TLE has not been fully elucidated yet. This study was designed to investigate the relation between the serum level of APOE and cognition in TLE patients. Sixty-five subjects (35 TLE patients and 30 healthy matched controls) were included. Evaluation of cognitive functions was done using Addenbrooke’s Cognitive Examination Revised (ACE-R) scale. Serum APOE level was measured by ELISA. The mean total score, memory and visuospatial scores of ACE-R were significantly lower in TLE patients compared to healthy subjects. The mean total score and memory score of ACE-R were significantly lower in seizures originating from mesial temporal lobe (MTL) and left temporal lobe seizures. Serum APOE levels were significantly higher in TLE patients compared to healthy subjects. Serum APOE levels significantly negatively correlated with total score, memory, and visuospatial ability scores of ACE-R. Serum APOE was significantly higher in MTL seizures compared to lateral lobe seizures and in left temporal lobe seizures compared to right temporal seizures. Memory and visuospatial aspects were significantly affected in TLE patients. So, the serum APOE level can possibly contribute to cognitive dysfunction in such patients.

Keywords

Cognition Temporal lobe epilepsy Apolipoprotein E 

Notes

Acknowledgements

The authors acknowledge subjects for their participation and cooperation in this study.

Author contributions

EE: research conception, EF: research idea and conception, data acquisition, data analysis and interpretation, and manuscript writing and reviewing, SS: performing and reviewing the laboratory workup, RSI: data interpretation, manuscript writing and reviewing, KE: data acquisition, data analysis and interpretation.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that the research was conducted in absence of any commercial relationships that could be construed as a potential conflict of interest.

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Copyright information

© Belgian Neurological Society 2019

Authors and Affiliations

  • Iman Elbanhawy
    • 1
  • Ebtesam Mohamed Fahmy
    • 1
  • Sahar Sharaf
    • 2
  • Rania Shehata Ismail
    • 1
    Email author
  • Karim Elmehdawy
    • 1
  1. 1.Department of Neurology, Faculty of MedicineCairo UniversityGizaEgypt
  2. 2.Department of Clinical Pathology, Faculty of MedicineCairo UniversityGizaEgypt

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