Association between serum apolipoprotein E and cognitive functions in Egyptian patients with temporal lobe epilepsy
Memory, cognition and visuospatial aspects of temporal lobe epilepsy (TLE) have not been fully analyzed yet. From among the huge growing population of circulating apoproteins analyzed in TLE, apolipoprotein E (APOE) was discovered; however, its role in TLE has not been fully elucidated yet. This study was designed to investigate the relation between the serum level of APOE and cognition in TLE patients. Sixty-five subjects (35 TLE patients and 30 healthy matched controls) were included. Evaluation of cognitive functions was done using Addenbrooke’s Cognitive Examination Revised (ACE-R) scale. Serum APOE level was measured by ELISA. The mean total score, memory and visuospatial scores of ACE-R were significantly lower in TLE patients compared to healthy subjects. The mean total score and memory score of ACE-R were significantly lower in seizures originating from mesial temporal lobe (MTL) and left temporal lobe seizures. Serum APOE levels were significantly higher in TLE patients compared to healthy subjects. Serum APOE levels significantly negatively correlated with total score, memory, and visuospatial ability scores of ACE-R. Serum APOE was significantly higher in MTL seizures compared to lateral lobe seizures and in left temporal lobe seizures compared to right temporal seizures. Memory and visuospatial aspects were significantly affected in TLE patients. So, the serum APOE level can possibly contribute to cognitive dysfunction in such patients.
KeywordsCognition Temporal lobe epilepsy Apolipoprotein E
The authors acknowledge subjects for their participation and cooperation in this study.
EE: research conception, EF: research idea and conception, data acquisition, data analysis and interpretation, and manuscript writing and reviewing, SS: performing and reviewing the laboratory workup, RSI: data interpretation, manuscript writing and reviewing, KE: data acquisition, data analysis and interpretation.
This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Compliance with ethical standards
Conflict of interest
The authors declare that the research was conducted in absence of any commercial relationships that could be construed as a potential conflict of interest.
- 5.Palop JJ, Mucke L (2009) Epilepsy and cognitive impairments in Alzheimer disease. ArchNeurol 66(4):435–440Google Scholar
- 7.Hermann S (2007) Classification of epileptic seizures. Continuum: lifelong learning in neurology. Epilepsy 13(4):13–47Google Scholar
- 14.Tavakoli M, Barekatain M, Doust HT, Molavi H, Nouri RK, Moradi A (2011) Cognitive impairments in patients with intractable temporal lobe epilepsy. J Res Med Sci 16:1466–1472Google Scholar